Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Description

Recombinant Human NACHT, LRR and PYD domains-containing protein 3(NLRP3),partial expressed in E.coli
Specifications

Uniprot ID: Q96P20; Host: Homo sapiens (Human); Expression system: E.coli; Expression region: 1-536aa; Sequence information: Partial; Tag: N-terminal 6xHis-tagged; Purity: Greater than 90% as determined by SDS-PAGE.
Additional_information

MW: 66.1 kDa; Buffer composition: Tris-based buffer with 50% glycerol.
Storage_and_shipping

Shipped on ice packs (+4°C). The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. Repeated freezing and thawing should be avoided. Store working aliquots at 4°C for up to one week.
Notes

For research use only.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Gene target

NACHT LRR PYD domains protein NLRP3
Gene symbol

LRR1, NLRP14, NLRP3
Short name

NACHT, LRR PYD domains- protein 3 (NLRP3)
Species

Human, Humans
Alternative name

H. sapiens NACHT, LRR and PYD domains-containing protein 3 (NLR family, pyrin domain containing 3)
Alternative to gene target

NLR family, pyrin domain containing 3, NLRP3 and IDBG-107914 and ENSG00000162711 and 114548, peptidoglycan binding, Cytoplasm, Nlrp3 and IDBG-178924 and ENSMUSG00000032691 and 216799, NLRP3 and IDBG-645402 and ENSBTAG00000001273 and 538639

Identity

HGNC:22939
Gene

NLRP14
Long gene name

NLR family pyrin domain containing 14
Synonyms gene
- NALP14
Synonyms gene name
- NACHT, leucine rich repeat and PYD containing 14
Synonyms
- NOD5
- GC-LRR
- Nalp-iota
- PAN8
- CLR11.2
Synonyms name
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 14
GenBank acession
- BK001107
Locus

11p15.4
Discovery year

2003-10-28
Entrez gene record

338323
Pubmed identfication
- 12563287
RefSeq identity
- NM_176822
Classification
- NLR family
- Pyrin domain containing
VEGA ID

OTTHUMG00000165508

Identity

HGNC:16400
Gene

NLRP3
Long gene name

NLR family pyrin domain containing 3
Synonyms gene
- C1orf7
- CIAS1
- DFNA34
Synonyms gene name
- cold autoinflammatory syndrome 1
- deafness, autosomal dominant 34
Synonyms
- AGTAVPRL
- AII
- AVP
- FCAS
- FCU
- NALP3
- PYPAF1
- MWS
- CLR1.1
Synonyms name
- Cryopyrin
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
GenBank acession
- AF054176
Locus

1q44
Discovery year

2001-08-28
Entrez gene record

114548
Pubmed identfication
- 10741953
RefSeq identity
- NM_004895
Classification
- Pyrin domain containing
- NLR family
VEGA ID

OTTHUMG00000040647
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_197