Human DNA repair protein complementing XP-C cells (XPC)

Description

Recombinant Human DNA repair protein complementing XP-C cells(XPC) ,partial expressed in E.coli
Specifications

Uniprot ID: Q01831; Host: Homo sapiens (Human); Expression system: E.coli; Expression region: 496-734aa; Sequence information: Partial; Tag: N-terminal 6xHis-tagged; Purity: Greater than 90% as determined by SDS-PAGE.
Additional_information

MW: 31.5 kDa; Buffer composition: Tris-based buffer with 50% glycerol.
Storage_and_shipping

Shipped on ice packs (+4°C). The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. Repeated freezing and thawing should be avoided. Store working aliquots at 4°C for up to one week.
Notes

For research use only.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Gene target

DNA repair protein complementing XP-C cells XPC
Gene symbol

XPC-AS1, XPC, POLH, SMC4, PRKDC, PCK1, MYB, MAGEB2, MAGEB1, MKRN4P
Short name

DNA repair protein complementing XP-C cells (XPC)
Technique

dna
Species

Human, Humans
Alternative name

H. sapiens Desoxyribonucleic acid repair protein complementing XP-C cells (xeroderma pigmentosum, complementation group C)
Alternative to gene target

xeroderma pigmentosum, complementation group C, p125 and RAD4 and XP3 and XPCC, XPC and IDBG-19992 and ENSG00000154767 and 7508, protein binding, nuclei, Xpc and IDBG-170258 and ENSMUSG00000030094 and 22591, XPC and IDBG-646437 and ENSBTAG00000007362 and 524274
Tissue

cells

Identity

HGNC:14013
Gene

SMC4
Long gene name

structural maintenance of chromosomes 4
Synonyms gene
- SMC4L1
Synonyms gene name
- SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
- SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
Synonyms
- hCAP-C
- CAP-C
GenBank acession
- AF092564
Locus

3q25.33
Discovery year

2001-02-22
Entrez gene record

10051
Pubmed identfication
- 9789013
- 10319587
Classification
- Structural maintenance of chromosomes proteins
- Condensin I subunits
- Condensin II subunits
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000159006

Identity

HGNC:6808
Gene

MAGEB1
Long gene name

MAGE family member B1
Synonyms gene name
- melanoma antigen family B1
Synonyms
- MAGEL1
- MAGE-Xp
- DAM10
- MGC9322
- CT3.1
Synonyms name
- DSS/AHC critical interval MAGE superfamily 10
- cancer/testis antigen family 3, member 1
Locus

Xp21.2
Discovery year

1997-08-15
Entrez gene record

4112
Pubmed identfication
- 7761436
- 9441743
RefSeq identity
- NM_002363
Classification
- MAGE family
VEGA ID

OTTHUMG00000021322
Locus Specific Databases
- Global Variome shared LOVD

Identity

HGNC:7115
Gene

MKRN4P
Long gene name

makorin ring finger protein 4, pseudogene
Synonyms gene
- ZNF127L1
- MKRN4
- MKRNP5
Synonyms gene name
- makorin, ring finger protein, 4
- makorin ring finger protein pseudogene 5
Synonyms
- ZNF-Xp
- RNF64
GenBank acession
- U41315
Locus

Xp11.4
Discovery year

1992-11-06
Entrez gene record

7682
RefSeq identity
- NG_004713
Classification
- Ring finger proteins
VEGA ID

OTTHUMG00000024109

Name

Targeted Gene Repair
Concept

Scope note: A technique which uses synthetic oligonucleotides to direct the cell's inherent DNA repair system to correct a mutation at a specific site in an episome or chromosome.
Tree numbers
- E02.095.301.500
- E05.393.420.301.500
- E05.393.420.601.575.500
Qualifiers

legislation & jurisprudence, ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data