Human CD40 ligand (CD40LG)

Description

Recombinant Human CD40 ligand(CD40LG),partial expressed in E.coli
Specifications

Uniprot ID: P29965; Host: Homo sapiens (Human); Expression system: E.coli; Expression region: 47-258aa; Sequence information: Extracellular Domain; Tag: N-terminal GST-tagged; Purity: Greater than 90% as determined by SDS-PAGE.
Additional_information

MW: 50.8 kDa; Buffer composition: Tris-based buffer with 50% glycerol.
Storage_and_shipping

Shipped on ice packs (+4°C). The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. Repeated freezing and thawing should be avoided. Store working aliquots at 4°C for up to one week.
Notes

For research use only.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional description

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.

Gene target

CD40 ligand CD40LG
Gene symbol

CD40, CD40LG
Short name

CD40 ligand (CD40LG)
Species

Human, Humans
Alternative name

H. sapiens CD40 molecule, tumor necrosis factor receptor superfamily member 5 ligand (CD40 molecule, tumor necrosis factor receptor superfamily member 5 ligand)
Alternative to gene target

CD40 molecule, TNF receptor superfamily member 5, Bp50 and CDW40 and p50 and TNFRSF5, CD40 and IDBG-78904 and ENSG00000101017 and 958, ubiquitin protein ligase binding, Extracellular, Cd40 and IDBG-212533 and ENSMUSG00000017652 and 21939, BT.42498 and IDBG-643036 and ENSBTAG00000020736 and 286849

Identity

HGNC:11919
Gene

CD40
Long gene name

CD40 molecule
Synonyms gene
- TNFRSF5
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 5
- CD40 molecule, TNF receptor superfamily member 5
Synonyms
- p50
- Bp50
GenBank acession
- X60592
Locus

20q13.12
Discovery year

1993-08-27
Entrez gene record

958
Pubmed identfication
- 7687385
- 2998589
RefSeq identity
- NM_001250
Classification
- CD molecules
- Tumor necrosis factor receptor superfamily
VEGA ID

OTTHUMG00000033053
Locus Specific Databases
- CD40base: Mutation registry for CD40 deficiency (previously known as TNFRSF5base)
- LRG_40

Identity

HGNC:11935
Gene

CD40LG
Long gene name

CD40 ligand
Synonyms gene
- HIGM1
- IMD3
- TNFSF5
Synonyms gene name
- tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
Synonyms
- CD40L
- TRAP
- gp39
- hCD40L
- CD154
Synonyms name
GenBank acession
- X67878
Locus

Xq26.3
Discovery year

1989-06-30
Entrez gene record

959
Pubmed identfication
- 1427881
- 7678782
RefSeq identity
- NM_000074
Classification
- CD molecules
- Tumor necrosis factor superfamily
VEGA ID

OTTHUMG00000022512
Locus Specific Databases

Name

CD4 Lymphocyte Count
Concept

Scope note: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
Tree numbers
- E01.370.225.500.195.107.595.500.150
- E01.370.225.625.107.595.500.150
- E05.200.500.195.107.595.500.150
- E05.200.625.107.595.500.150
- E05.242.195.107.595.500.150
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data