Recombinant Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR)

• Catalog number
  RPB662Mu01-200ug
• Price
  Please ask
• Size
  200ug

• Description
  Recombinant Mouse Glucocorticoid Induced Tumor Necrosis Factor Receptor expressed in: E.coli
• Specifications
  Host species: Mus musculus (Mouse); Expression system: E.coli; Expression region: Gln20~His153; Purity: > 90%; Endotoxin level:
• Additional_information
  Uniprot ID: O35714; Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.; Form: Freeze-dried powder; Predicted Molecular Mass (KD): 18.3kDa; Isoelectric Point: 7
• Storage_and_shipping
  Shipped on ice packs. Upon receipt keep at 2-8 °C for up to 1 month. For long term storage prepare working aliquots and keep frozen at -20 or -80 °C. Avoid repeated freezing and thawing.
• Notes
  Research Use Only.
• Additional description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Induced protein genes, factors or kinases, increase the production of (an enzyme or other protein) at the level of genetic transcription. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Glucocorticoid   Tumor   Necrosis   Factor   Receptor   GITR  
• Gene symbol
  TNFRSF18
• Short name
  Recombinant Glucocorticoid Tumor Necrosis Factor Receptor (GITR)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Cloud Clone Corp advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Rec. Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR)
• Alternative technique
  rec
• Tissue
  tumor

Gene info

• Identity
  HGNC:11914
• Gene
  TNFRSF18
• Long gene name
  TNF receptor superfamily member 18
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 18
• Synonyms
  • AITR
  • GITR
  • CD357
• GenBank acession
  • AF125304
• Locus
  1p36.33
• Discovery year
  1998-12-04
• Entrez gene record
  8784
• Pubmed identfication
  • 9177197
  • 10037686
• RefSeq identity
  • NM_004195
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000001414

MeSH Data

• Name
  Tumor Stem Cell Assay
• Concept
  Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
• Tree numbers
  • E01.370.225.500.383.910
  • E01.370.225.500.388.930
  • E05.200.500.383.910
  • E05.200.500.388.930
  • E05.242.383.910
  • E05.242.417.500
  • E05.337.550.200.800
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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