OVA Conjugated Wilms Tumor Protein (WT1)

Source

Protein conjugation
Predicted Molecular Mass KD

NA
Accurate Molecular Mass KD

NA
Organism species

Homo sapiens (Human)
Item Name

Wilms Tumor Protein
Alternative Names

WAGR; GUD; WIT-2; WT33
Research Area

Tumor immunity;
Buffer Formulation

PBS, pH7.4.
Traits

Freeze-dried powder
Purity

> 90%
Protein length

Thr402-Ser415
Tag

N-terminal His Tag
Expression System

Protein conjugation
Application

Immunogen; SDS-PAGE; WB.
Manual link
Gene

Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein. OVA is also the best characterized and the first antigen proteins used as a transgene to make transgenic mice. Many different transgenic mouse models have systemic OVA expression driven by the ubiquitously expressed b-actin promoter or tissue-specific OVA expression with insulin promoter to drive the transgene expression, for studying type I diabetes, or in different isoforms, secreted or cell-membrane associated, and more recently as inducible transgene models. These C57BL/6 mice, BALB/c mice models are well characterized, and have contributed to our understanding of immunogenicity and tolerance by the OVA model.

Gene target

OVA Conjugated Wilms Tumor Protein WT1
Gene symbol

WT1-AS, WT1
Short name

OVA Conjugated Wilms Tumor Protein (WT1)
Technique

antibody Conjugates
Host

Protein conjugation
Species

Homo sapiens (Human)
Alternative name

OVA coupled Wilms Tumor Protein (Wilms tumor 1)
Alternative to gene target

Wilms tumor 1, AWT1 and EWS-WT1 and GUD and NPHS4 and WAGR and WIT-2 and WT33, WT1 and IDBG-37982 and ENSG00000184937 and 7490, C2H2 zinc finger domain binding, nuclei, Wt1 and IDBG-194872 and ENSMUSG00000016458 and 22431, WT1 and IDBG-636230 and ENSBTAG00000047268 and 782183
Tissue

tumor

Identity

HGNC:18135
Gene

WT1-AS
Long gene name

WT1 antisense RNA
Synonyms gene
- WIT1
Synonyms gene name
- Wilms tumor upstream neighbor 1
- WT1 antisense RNA (non-protein coding)
Synonyms
- WIT-1
- WT1AS
- WT1-AS1
Synonyms name
- Wilms tumor associated protein
GenBank acession
- BC002734
Locus

11p13
Discovery year

2005-10-28
Entrez gene record

51352
Pubmed identfication
- 2173145
- 8406502
- 17210670
RefSeq identity
- NR_023920
Classification
- Antisense RNAs
VEGA ID

OTTHUMG00000039557

Name

Tumor Stem Cell Assay
Concept

Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
Tree numbers
- E01.370.225.500.383.910
- E01.370.225.500.388.930
- E05.200.500.383.910
- E05.200.500.388.930
- E05.242.383.910
- E05.242.417.500
- E05.337.550.200.800
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data