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Target antigen
TRPC4
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TRPC4(961-977aa LNLPDTVTHEDYVTTRL).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the TRPC4 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The TRPC4 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
The short transient receptor potential channel 4(TRPC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene. TRPC4 is a member of the transient receptor potential cation channels. It is mapped to 13q13.3. This protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors andtyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. TRPC4 also has an essential role in endothelial-dependent regulation of vascular tone, endothelial permeability, and neurotransmitter release from thalamic interneurons.
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Related articles
1. "Entrez Gene: transient receptor potential cation channel, subfamily C, member 4" 2. Freichel, M., Vennekens, R., Olausson, J., Hoffmann, M., Muller, C., Stolz, S., Scheunemann, J., Weissgerber, P., Flockerzi, V. Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models. Biochem. Biophys. Res. Commun. 322: 1352-1358, 2004. 3. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L (May 1996). "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry". Cell 85 (5): 661–71.
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Gene Name
TRPC4
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Protein Name
Short transient receptor potential channel 4
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Gene Full Name
transient receptor potential cation channel, subfamily C, member 4
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Synonyms
CCE1 antibody|HTRP 4 antibody|hTrp-4 antibody|HTRP4 antibody|MGC119570 antibody|MGC119571 antibody|MGC119572 antibody|MGC119573 antibody|RP11-10M8.1 antibody|Short transient receptor potential channel 4 antibody|STRPC4 antibody|Transient receptor potential 4 antibody|transient receptor potential cation channel subfamily C antibody|Transient receptor potential cation channel subfamily C member 4 antibody|transient receptor potential channel 4 antibody|TRP 4 antibody|trp related protein 4 antibody|Trp-related protein 4 antibody|TRP4 antibody|TRPC 4 antibody|TrpC4 antibody|TRPC4 protein antibody|TRPC4_HUMAN antibody
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Uniprot ID
Q9UBN4
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
