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Target antigen
Transferrin Receptor 2
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat Predicted to work with: mouse
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of mouse Transferrin Receptor 2(1-15aa MEQRWGLLRRVQQWS), different from the related rat sequence by one amino acid.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Transferrin Receptor 2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Transferrin Receptor 2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
TFR2(Transferrin receptor protein 2), is a protein that in humans is encoded by the TFR2 gene. This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated(PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. By radiation hybrid analysis, Kawabata et al.(1999) mapped the TFR2 gene to chromosome 7q22.The majority of hepatic iron uptake under normal circumstances is transferrin-mediated. However, expression of TFRC in hepatocytes, as in other nonreticuloendothelial cell types, is downregulated in response to increased intracellular iron. As a consequence, TFRC expression in liver is undetectable in hereditary hemochromatosis patients with hepatic iron loading. Nonetheless, hepatic iron loading in hemochromatosis patients is progressive. Fleming et al.(2000) provided support for a mechanism that involves the uptake of transferrin-bound iron by TFR2.
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Related articles
1. Fleming, R. E., Migas, M. C., Holden, C. C., Waheed, A., Britton, R. S., Tomatsu, S., Bacon, B. R., Sly, W. S.Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis.Proc. Nat. Acad. Sci. 97: 2214-2219, 2000. 2. Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., Koeffler, H. P.Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family.J. Biol. Chem. 274: 20826-20832, 1999. 3. Mattman, A., Huntsman, D., Lockitch, G., Langlois, S., Buskard, N., Ralston, D., Butterfield, Y., Rodrigues, P., Jones, S., Porto, G., Marra, M., De Sousa, M., Vatcher, G.Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation.Blood 100: 1075-1077, 2002.
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Gene Name
TFR2
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Protein Name
Transferrin receptor protein 2
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Gene Full Name
transferrin receptor 2
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Synonyms
HFE 3 antibody|HFE3 antibody|MGC126368 antibody|TFR 2 antibody|TFR2 antibody|TFR2_HUMAN antibody|TFRC 2 antibody|TFRC2 antibody|Transferrin receptor 2 antibody|Transferrin receptor protein 2 antibody
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Uniprot ID
Q9JKX3
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translation
anticorps
