TORC2 Antibody
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Catalog numberPA1988
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PricePlease ask
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Size0,1 mg
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Target antigenTORC2
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman
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AnalysesWB
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ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human TORC2(595-611aa QDPHTFNHQNLTHCSRH), different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the TORC2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe TORC2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundCRTC2(CREB-Regulated Transcription Coactivator 2), also known as TORC2, is a protein that in humans is encoded by the CRTC2 gene. The International Radiation Hybrid Mapping Consortium mapped the CRTC2 gene to chromosome 1. By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al.(2003) found that TORC2 potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences. Liu et al.(2008) demonstrated that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1(SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. Using mice and primary mouse hepatocytes, Wang et al.(2009) found that Crtc2 functioned as a dual sensor for endoplasmic reticulum(ER) stress and fasting signals.
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Related articles1. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L., Meltzer, J., Garza, D., Chirn, G.-W., McWhinnie, E., and 9 others. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Nat. Acad. Sci. 100: 12147-12152, 2003. 2. Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., Yates, J., III, Olefsky, J., Guarente, L., Montminy, M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273, 2008. 3. Wang, Y., Vera, L., Fischer, W. H., Montminy, M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460: 534-537, 2009.
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Gene NameCRTC2
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Protein NameCREB-regulated transcription coactivator 2
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Gene Full NameCREB regulated transcription coactivator 2
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SynonymsCREB regulated transcription coactivator 2 antibody|CREB-regulated transcription coactivator 2 antibody|CRTC2 antibody|CRTC2_HUMAN antibody|RP11-422P24.6 antibody|TORC-2 antibody|torc2 antibody|Transducer of CREB protein 2 antibody|Transducer of regulated cAMP response element-binding protein antibody|Transducer of regulated cAMP response element-binding protein(CREB) 2 antibody|Transducer of regulated cAMP response element-binding protein 2 antibody|Transducer of regulated CREB protein 2 antibody
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Uniprot IDQ53ET0
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCRTC2
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Short nameTORC2 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameTORC2 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameCREB regulated transcription coactivator 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-11-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data