TFPI Antibody

• Catalog number
  A01052
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  TFPI
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB
• Immunogen
  E.coli-derived human TFPI recombinant protein (Position: N253-M304). Human TFPI shares 51.1% and 53.2% amino acid (aa) sequence identity with mouse and rat TFPI, respectively.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the TFPI Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The TFPI Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  TFPI (Tissue factor pathway inhibitor) also known as EPI, LACI, TFI and TFPT1 is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.
• Related articles
  1. Enjyoji, K.-I., Emi, M., Mukai, T., Imada, M., Leppert, M. L., Lalouel, J. M., Kato, H.Human tissue factor pathway inhibitor (TFPI) gene: complete genomic structure and localization on the genetic map of chromosome 2q.Genomics 17: 423-428, 1993. 2. Kleesiek, K., Schmidt, M., Gotting, C., Brinkmann, T., Prohaska, W.A first mutation in the human tissue factor pathway inhibitor gene encoding (P151L) TFPI. (Letter)Blood 92: 3976-3977, 1998. 3. Lupu, C., Zhu, H., Popescu, N. I., Wren, J. D., Lupu, F.Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen.Blood 118: 4463-4471, 2011.
• Gene Name
  TFPI
• Protein Name
  Tissue factor pathway inhibitor
• Gene Full Name
  tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
• Synonyms
  Tissue factor pathway inhibitor | TFPI | Extrinsic pathway inhibitor | EPI | Lipoprotein-associated coagulation inhibitor | LACI | TFPI1 | P10646
• Uniprot ID
  P10646
• Entrez GeneID
  7035
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TFPI  
• Gene symbol
  TFPI, TFPI2
• Short name
  TFPI Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  TFPI (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11760
• Gene
  TFPI
• Long gene name
  tissue factor pathway inhibitor
• Synonyms gene
  • LACI
• Synonyms gene name
  • tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
• Synonyms
  • EPI
  • TFI
  • TFPI1
• Synonyms name
  • extrinsic pathway inhibitor
• Locus
  2q32.1
• Discovery year
  1991-06-03
• Entrez gene record
  7035
• Pubmed identfication
  • 1993173
• RefSeq identity
  • NM_006287
• VEGA ID
  OTTHUMG00000132634
• Locus Specific Databases
  • LRG_604

Gene info

• Identity
  HGNC:11761
• Gene
  TFPI2
• Long gene name
  tissue factor pathway inhibitor 2
• Synonyms
  • PP5
  • TFPI-2
  • REF1
• GenBank acession
  • L27624
• Locus
  7q21.3
• Discovery year
  1999-07-14
• Entrez gene record
  7980
• Pubmed identfication
  • 7896752
  • 8945635
• RefSeq identity
  • NM_006528
• VEGA ID
  OTTHUMG00000022963
• Locus Specific Databases
  • LRG_647

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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