SLC6A4 Antibody

• Catalog number
  RP1068
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  SLC6A4
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  rat Theoretical reactivity:human
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human SLC6A4 (57-85aa DDTRHSIPATTTTLVAELHQGERETWGKK), different from the related mouse and rat sequences by six amino acids.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the SLC6A4 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The SLC6A4 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  SLC6A4 (Solute carrier family 6, member 4), also known as SERT(serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium: neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.
• Related articles
  1. Kim, S.-J., Cox, N., Courchesne, R., Lord, C., Corsello, C., Akshoomoff, N., Guter, S., Leventhal, B. L., Courchesne, E., Cook, E. H., Jr.Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder.Molec. Psychiat. 7: 278-288, 2002. 2. Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., Murphy, D. L.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.Science 274: 1527-1530, 1996. 3. Shen, S., Battersby, S., Weaver, M., Clark, E., Stephens, K., Harmar, A. J.Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes.Europ. J. Hum. Genet. 8: 75-78, 2000.
• Gene Name
  SLC6A4
• Protein Name
  Sodium-dependent serotonin transporter
• Gene Full Name
  solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
• Synonyms
  5 HTT antibody|5 HTTLPR antibody|5 hydroxytryptamine (serotonin) transporter antibody|5 hydroxytryptamine transporter antibody|5HT transporter antibody|5HTT antibody|hSERT antibody|HTT antibody|Na+/Cl- dependent serotonin transporter antibody|OCD1 antibody|SC6A4_HUMAN antibody|Serotonin transporter 1 antibody|SERT antibody|SERT1 antibody|SLC6A4 antibody|Sodium dependent serotonin transporter antibody|Sodium-dependent serotonin transporter antibody|Solute carrier family 6 (neurotransmitter transporter) member 4 antibody|solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 antibody|Solute carrier family 6 member 4 antibody
• Uniprot ID
  P31645
• Entrez GeneID
  6532
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SLC6A4  
• Gene symbol
  SLC6A4
• Short name
  SLC6A4 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  SLC6A4 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11050
• Gene
  SLC6A4
• Long gene name
  solute carrier family 6 member 4
• Synonyms gene
  • HTT
  • OCD1
• Synonyms gene name
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • 5-hydroxytryptamine (serotonin) transporter
  • obsessive-compulsive disorder 1
  • solute carrier family 6 (neurotransmitter transporter), member 4
• Synonyms
  • 5-HTT
  • SERT1
• Synonyms name
  • serotonin transporter 1
• GenBank acession
  • L05568
• Locus
  17q11.2
• Discovery year
  1994-03-16
• Entrez gene record
  6532
• Pubmed identfication
  • 7681602
  • 19806148
• RefSeq identity
  • NM_001045
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000132751

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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