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Target antigen
Scn1a
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Scn1a (1981-2009aa ACPPSYDRVTKPIVEKHEQEGKDEKAKGK), identical to the related rat sequence.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Scn1a Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Scn1a Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Nav1.1, also known as the sodium channel, voltage-gated, type I, alpha subunit (SCN1A), is a protein which in humans is encoded by the SCN1A gene. Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.
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Related articles
1. "Entrez Gene: SCN1A sodium channel, voltage-gated, type I, alpha subunit". 2. Ito M, Nagafuji H, Okazawa H, Yamakawa K, Sugawara T, Mazaki-Miyazaki E, Hirose S, Fukuma G, Mitsudome A, Wada K, Kaneko S (Jan 2002)."Autosomal dominant epilepsy with febrile seizures plus with missense mutations of the (Na+)-channel alpha 1 subunit gene, SCN1A". Epilepsy Research 48 (1-2): 15–23. 3. Malo MS, Blanchard BJ, Andresen JM, Srivastava K, Chen XN, Li X, Jabs EW, Korenberg JR, Ingram VM (1994). "Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24". Cytogenetics and Cell Genetics 67 (3): 178–86.
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Gene Name
SCN1A
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Protein Name
Sodium channel protein type 1 subunit alpha
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Gene Full Name
sodium voltage-gated channel alpha subunit 1
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Synonyms
brain sodium channel type I antibody|EIEE6 antibody|FEB3 antibody|FEB3A antibody|FHM3 antibody|GEFS+2 antibody|GEFSP2 antibody|HBSC I antibody|HBSCI antibody|NAC1 antibody|Nav 1.1 antibody|RBI antibody|SCN1 antibody|Scn1a antibody|SCN1A_HUMAN antibody|SMEI antibody| Sodium channel protein brain I alpha subunit antibody|Sodium channel protein brain I subunit alpha antibody|Sodium channel protein type 1 subunit alpha antibody|Sodium channel protein type I subunit alpha antibody|Sodium channel voltage gated type 1 alpha subunit antibody|Sodium channel voltage gated type I alpha polypeptide antibody|Voltage-gated sodium channel subunit alpha Nav1.1 antibody
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Uniprot ID
P35498
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Entrez GeneID
6323
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
