RIP3 Antibody

• Catalog number
  PA2242
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  RIP3
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human RIP3(60-76aa EVKAMASLDNEFVLRLE).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the RIP3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The RIP3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Receptor-interacting serine/threonine-protein kinase 3(RIPK3), also known as RIP3 is an enzyme that in humans is encoded by the RIPK3 gene. This gene is mapped to 14q12. The product of this gene is a member of the receptor-interacting protein(RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor(TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
• Related articles
  1. Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., Mocarski, E. S. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471: 368-372, 2011. 2. Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., Wang, X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148: 213-227, 2012. 3. Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., Han, J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325: 332-336, 2009.
• Gene Name
  RIPK3
• Protein Name
  Receptor-interacting serine/threonine-protein kinase 3
• Gene Full Name
  receptor-interacting serine-threonine kinase 3
• Synonyms
  Receptor interacting protein 3 antibody|Receptor interacting serine threonine kinase 3 antibody|Receptor interacting serine/threonine protein kinase 3 antibody|Receptor-interacting protein 3 antibody|Receptor-interacting serine/threonine-protein kinase 3 antibody|RIP 3 antibody|RIP like protein kinase 3 antibody|RIP-3 antibody|RIP-like protein kinase 3 antibody|RIPK 3 antibody|RIPK3 antibody|RIPK3_HUMAN antibody
• Uniprot ID
  Q9Y572
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RIP3  
• Gene symbol
  RIPK3
• Short name
  RIP3 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  RIP3 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10021
• Gene
  RIPK3
• Long gene name
  receptor interacting serine/threonine kinase 3
• Synonyms gene name
  • receptor-interacting serine-threonine kinase 3
• Synonyms
  • RIP3
• GenBank acession
  • AF156884
• Locus
  14q12
• Discovery year
  1999-12-17
• Entrez gene record
  11035
• Pubmed identfication
  • 10339433
  • 10358032
• RefSeq identity
  • NM_006871
• VEGA ID
  OTTHUMG00000029349

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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