PPP1R15B Antibody

• Catalog number
  PA1714
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  PPP1R15B
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat Predicted to work with: mouse
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human PPP1R15B(15-31aa RAGFRFWPPFFPRRSQA).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the PPP1R15B Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The PPP1R15B Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  PPP1R15B(Protein phosphatase 1, regulatory subunit 15b), also called CREP, promotes dephosphorylation of the transcription initiation factor EIF2-alpha through recruitment of protein phosphatase-1(PP1) catalytic subunits. The PPP1R15B gene is mapped to chromosome 1q32.1 based on an alignment of thePPP1R15B sequence by Hartz(2010). Harding et al.(2009) obtained Ppp1r15b -/- mice at a mendelian ratio. However, Ppp1r15b -/- newborns were half the size of their wildtype littermates, were notably pale, and failed to nurse, and none survived the first day of postnatal life. Ppp1r15b -/- embryos that were also homozygous for an Eif2-alpha mutation that prevented Eif2-alpha phosphorylation were normalized, including elevated birth size and restored red blood cell count, compared with Ppp1r15b -/- embryos with wildtype Eif2-alpha.
• Related articles
  1. Harding, H. P., Zhang, Y., Scheuner, D., Chen, J.-J., Kaufman, R. J., Ron, D. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2-alpha) dephosphorylation in mammalian development. Proc. Nat. Acad. Sci. 106: 1832-1837, 2009.
• Gene Name
  PPP1R15B
• Protein Name
  Protein phosphatase 1 regulatory subunit 15B
• Gene Full Name
  protein phosphatase 1, regulatory subunit 15B
• Synonyms
  CREP antibody|FLJ14744 antibody|PPP1R15B antibody|Protein phosphatase 1, regulatory(inhibitor) subunit 15B antibody|Protein phosphatase 1, regulatory subunit 15B antibody
• Uniprot ID
  Q5SWA1
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PPP1R15B  
• Gene symbol
  PPP1R15B-AS1, PPP1R15B
• Short name
  PPP1R15B Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  PPP1R15B (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:55838
• Gene
  PPP1R15B-AS1
• Long gene name
  PPP1R15B and PIK3C2B antisense RNA 1
• Locus
  1q32.1
• Discovery year
  2021-08-02
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:14951
• Gene
  PPP1R15B
• Long gene name
  protein phosphatase 1 regulatory subunit 15B
• Synonyms gene name
  • protein phosphatase 1, regulatory (inhibitor) subunit 15B
  • protein phosphatase 1, regulatory subunit 15B
• Synonyms
  • FLJ14744
• GenBank acession
  • AK027650
• Locus
  1q32.1
• Discovery year
  2001-06-29
• Entrez gene record
  84919
• Pubmed identfication
  • 11948623
• RefSeq identity
  • NM_032833
• Classification
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000036105

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products