PLGF Antibody

• Catalog number
  PA1066
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  PLGF
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human PLGF(206-221aa REKMKPERCGDAVPRR).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the PLGF Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The PLGF Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Placental growth factor(PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.
• Related articles
  1. Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG. Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14. Oncogene. 1993 Apr; 8(4):925-31. 2. Migdal M, Huppertz B, Tessler S, Comforti A, Shibuya M, Reich R, Baumann H, Neufeld G. Neuropilin-1 is a placenta growth factor-2 receptor. J Biol Chem. 1998 Aug 28; 273(35):22272-8. 3. Autiero M, Waltenberger J, Communi D, Kranz A, Moons L, Lambrechts D, Kroll J, Plaisance S, De Mol M, Bono F, Kliche S, Fellbrich G, Ballmer-Hofer K, Maglione D, Mayr-Beyrle U, Dewerchin M, Dombrowski S, Stanimirovic D, Van Hummelen P, Dehio C, Hicklin DJ, Persico G, Herbert JM, Communi D, Shibuya M, Collen D, Conway EM, Carmeliet P. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med. 2003 Jul; 9(7):936-43. 4. Christinger HW, Fuh G, de Vos AM, Wiesmann C. The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1. J Biol Chem. 2004 Mar 12; 279(11):10382-8.
• Gene Name
  PGF
• Protein Name
  Placenta growth factor(PlGF)
• Gene Full Name
  placental growth factor
• Synonyms
  PGF antibody|PGFL antibody|PIGF antibody|Placenta growth factor antibody|placental growth factor antibody|Placental growth factor vascular endothelial growth factor related protein antibody|PlGF 2 antibody|PlGF antibody|PLGF_HUMAN antibody|PlGF2 antibody|Vascular endothelial growth factor related protein antibody
• Uniprot ID
  P49763
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PLGF  
• Gene symbol
  PGF
• Short name
  PLGF Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  PLGF (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8893
• Gene
  PGF
• Long gene name
  placental growth factor
• Synonyms gene
  • PGFL
• Synonyms gene name
  • placental growth factor-like
  • placental growth factor, vascular endothelial growth factor-related protein
• Synonyms
  • PlGF-2
  • SHGC-10760
  • D12S1900
  • PIGF
  • PLGF
  • PlGF
• Synonyms name
  • placenta growth factor
• GenBank acession
  • S72960
• Locus
  14q24.3
• Discovery year
  1994-01-14
• Entrez gene record
  5228
• Pubmed identfication
  • 7681160
• RefSeq identity
  • NM_002632
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000171496

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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