Periplakin Antibody

• Catalog number
  A02098-1
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Periplakin
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human Periplakin (1664-1701aa DTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVK), different from the related mouse sequence by one amino acid.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Periplakin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Periplakin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Periplakin is a protein that in humans is encoded by the PPL gene. The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
• Related articles
  1. "Entrez Gene: PPL periplakin". 2. Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics. 48 (2): 242–7. 3. Kazerounian, Shideh; Uitto Jouni; Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. Denmark. 11(5): 428–38.
• Gene Name
  PPL
• Protein Name
  Periplakin
• Gene Full Name
  periplakin
• Synonyms
  Periplakin | ppl | O60437
• Uniprot ID
  O60437
• Entrez GeneID
  5493
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Periplakin  
• Gene symbol
  PPL, KAZN
• Short name
  Periplakin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Periplakin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9273
• Gene
  PPL
• Long gene name
  periplakin
• GenBank acession
  • AF013717
• Locus
  16p13.3
• Discovery year
  1997-08-22
• Entrez gene record
  5493
• Pubmed identfication
  • 9570964
  • 9521878
• RefSeq identity
  • NM_002705
• Classification
  • Plakins
• VEGA ID
  OTTHUMG00000129528

Gene info

• Identity
  HGNC:29173
• Gene
  KAZN
• Long gene name
  kazrin, periplakin interacting protein
• Synonyms gene
  • C1orf196
• Synonyms gene name
  • chromosome 1 open reading frame 196
• Synonyms
  • KIAA1026
  • KAZRIN
  • FLJ43806
• GenBank acession
  • AY505119
• Locus
  1p36.21
• Discovery year
  2011-01-31
• Entrez gene record
  23254
• Pubmed identfication
  • 15337775
  • 18840647
• RefSeq identity
  • NM_001017999
• Classification
  • Sterile alpha motif domain containing
• VEGA ID
  OTTHUMG00000002042

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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