P2X2 Antibody
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Catalog numberPB9303
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PricePlease ask
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Size0,1 mg
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Target antigenP2X2
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman, mouse, rat
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AnalysesWB,IHC-P
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ImmunogenE.coli-derived human P2X2 recombinant protein (Position: D139-L471). Human P2X2 shares 84% amino acid (aa) sequence identity with both mouse and rat P2X2.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the P2X2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe P2X2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundThe P2RX2 gene encodes the P2X2 receptor, which assembles as a trimer to form a ligand-gated ion channel gated by extracellular ATP. P2X2 receptors mediate a variety of cellular responses, including excitatory postsynaptic responses in sensory neurons. The product of this gene belongs to the family of purinoceptors for ATP. P2RX2 is mapped to 12q24.33. It has been found that ATP-activated P2RX2 influenced OHC electromotility, a stimulus-induced change in hair cell length that functions as an amplifier to determine hearing sensitivity and frequency selectivity. What’s more, P2RX2 channels were necessary for development of the temporary threshold shift.
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Related articles1. Housley, G. D., Morton-Jones, R., Vlajkovic, S. M., Telang, R. S., Paramananthasivam, V., Tadros, S. F., Wong, A. C. Y., Froud, K. E., Cederholm, J. M. E., Sivakumaran, Y., Snguanwongchai, P., Khakh, B. S., Cockayne, D. A., Thorne, P. R., Ryan, A. F. ATP-gated ion channels mediate adaptation to elevated sound levels. Proc. Nat. Acad. Sci. 110: 7494-7499, 2013. 2. Yan, D., Zhu, Y., Walsh, T., Xie, D., Yuan, H., Sirmaci, A., Fujikawa, T., Wong, A. C. Y., Loh, T. L., Du, L., Grati, M., Vlajkovic, S. M., and 10 others. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc. Nat. Acad. Sci. 110: 2228-2233, 2013. 3. Yu, N., Zhao, H.-B. ATP activates P2x receptors and requires extracellular Ca(++) participation to modify outer hair cell nonlinear capacitance. Pflugers Arch. 457: 453-461, 2008.
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Gene NameP2RX2
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Protein NameP2X purinoceptor 2
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Gene Full Namepurinergic receptor P2X, ligand gated ion channel, 2
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SynonymsATP receptor antibody|MGC129601 antibody|P2RX 2 antibody|P2RX2 antibody|P2RX2_HUMAN antibody|P2X purinoceptor 2 antibody|P2X Receptor subunit 2 antibody|P2X2 antibody|P2X2a antibody|Purinergic receptor antibody|Purinergic receptor P2X ligand gated ion channel 2 antibody|Purinergic receptor P2X2 isoform A antibody|Purinergic receptor P2X2 isoform B antibody|Purinergic receptor P2X2 isoform C antibody|Purinergic receptor P2X2 isoform D antibody|Purinergic receptor P2X2 isoform H antibody|Purinergic receptor P2X2 isoform I antibody
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Uniprot IDQ9UBL9
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Entrez GeneID22953
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolP2RX2
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Short nameP2X2 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameP2X2 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namepurinergic receptor P2X 2
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Synonyms gene
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Synonyms gene name
- deafness, autosomal dominant 41
- purinergic receptor P2X, ligand-gated ion channel, 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-03-30
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Pubmed identfication
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Classification
- Purinergic receptors P2X
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data