Occludin Antibody

• Catalog number
  RP1057
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Occludin
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  mouse, rat Theoretical reactivity:human
• Analyses
  WB,IHC-P
• Immunogen
  E.coli-derived human Occludin recombinant protein (Position: N373-T522). Human Occludin shares 89% amino acid (aa) sequence identity with both mouse and rat Occludin.
• Product configuration
  Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Occludin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Occludin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Occludin is an integral membrane protein that is located at tight junctions. It is a member of a family of proteins containing the highly conserved Marvel domain, which contains 4 transmembrane-helix regions. This gene is mapped to 5q13.2. Occludin regulates TGF-beta receptor type I localization for efficient TGF-beta-dependent dissolution of tight junctions during epithelial-mesenchymal transitions. Human Occludin is an essential hepatitis C virus (HCV) cell entry factor that is able to render murine cells infectable with HCV glycoproteins. It has been found that occludin is involved in cell migration and functions to recruit active PI3 kinase to the leading edge, resulting in RAC1 activation and formation of lamellipodia.
• Related articles
  1. Ando-Akatsuka, Y., Saitou, M., Hirase, T., Kishi, M., Sakakibara, A., Itoh, M., Yonemura, S., Furuse, M., Tsukita, S. Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J. Cell Biol. 133: 43-47, 1996. 2. Barrios-Rodiles, M., Brown, K. R., Ozdamar, B., Bose, R., Liu, Z., Donovan, R. S., Shinjo, F., Liu, Y., Dembowy, J., Taylor, I. W., Luga, V., Przulj, N., Robinson, M., Suzuki, H., Hayashizaki, Y., Jurisica, I., Wrana, J. L. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307: 1621-1625, 2005. 3. Du, D., Xu, F., Yu, L., Zhang, C., Lu, X., Yuan, H., Huang, Q., Zhang, F., Bao, H., Jia, L., Wu, X., Zhu, X., Zhang, X., Zhang, Z., Chen, Z. The tight junction protein, occludin, regulates the directional migration of epithelial cells. Dev. Cell 18: 52-63, 2010.
• Gene Name
  OCLN
• Protein Name
  Occludin
• Gene Full Name
  occludin
• Synonyms
  BLCPMG antibody|FLJ08163 antibody|FLJ18079 antibody|FLJ77961 antibody|FLJ94056 antibody|MGC34277 antibody|Occludin antibody|OCLN antibody|OCLN_HUMAN antibody|Tight junction protein occludin antibody
• Uniprot ID
  Q16625
• Entrez GeneID
  100506658
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Occludin  
• Gene symbol
  OCLN, OCEL1, MARVELD1
• Short name
  Occludin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Occludin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8104
• Gene
  OCLN
• Long gene name
  occludin
• Synonyms
  • PPP1R115
• Synonyms name
  • tight junction protein occludin TM4 minus
  • phosphatase 1, regulatory subunit 115
• GenBank acession
  • U49184
• Locus
  5q13.2
• Discovery year
  1998-01-20
• Entrez gene record
  100506658
• Pubmed identfication
  • 8601611
• RefSeq identity
  • NM_002538
• Classification
  • Protein phosphatase 1 regulatory subunits
  • Tetraspan junctional complex superfamily
  • MARVEL domain containing
• VEGA ID
  OTTHUMG00000099356

Gene info

• Identity
  HGNC:26221
• Gene
  OCEL1
• Long gene name
  occludin/ELL domain containing 1
• Synonyms
  • FLJ22709
• GenBank acession
  • BC029361
• Locus
  19p13.11
• Discovery year
  2006-08-22
• Entrez gene record
  79629
• Pubmed identfication
  • 12477932
• RefSeq identity
  • NM_024578
• VEGA ID
  OTTHUMG00000182726

Gene info

• Identity
  HGNC:28674
• Gene
  MARVELD1
• Long gene name
  MARVEL domain containing 1
• Synonyms gene
  • MRVLDC1
• Synonyms gene name
  • MARVEL (membrane-associating) domain containing 1
• Synonyms
  • MGC4415
  • GB14
  • FLJ23440
  • FLJ22343
  • bA548K23.8
• Synonyms name
  • occludin
• GenBank acession
  • BC004995
• Locus
  10q24.2
• Discovery year
  2004-03-05
• Entrez gene record
  83742
• Pubmed identfication
  • 19364627
  • 21347699
• RefSeq identity
  • NM_031484
• Classification
  • MARVEL domain containing
• VEGA ID
  OTTHUMG00000018865

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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