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Target antigen
NMDAR2B
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human Predicted to work with: mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human NMDAR2B(1131-1146aa, DFYLDQFRTKENSPHW), identical to the related mouse and rat sequence.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the NMDAR2B Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The NMDAR2B Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
The N-methyl-D-aspartate receptor 2B, also names as GRIN2B. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse Nmdar2b proteins, respectively. Nmdar2B gene is located on mouse chromosome 6 between Rho and Ly49 centromerically and Glb telomerically. Mapping of the human NMDAR2B receptor subunit gene(GRIN2B) to chromosome 12p12 overexpression of NMDA receptor 2B(NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-100 Hz.
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Related articles
1. Mandich, P.; Schito, A. M.; Bellone, E.; Antonacci, R.; Finelli, P.; Rocchi, M.; Ajmar, F. : Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. Genomics 22: 216-218, 1994. 2. Tang, Y.-P.; Shimizu, E.; Dube, G. R.; Rampon, C.; Kerchner, G. A.; Zhuo, M.; Liu, G.; Tsien, J. Z. : Genetic enhancement of learning and memory in mice. Nature 401: 63-69, 1999.
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Gene Name
GRIN2B
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Protein Name
Glutamate receptor ionotropic, NMDA 2B
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Gene Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
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Synonyms
AW490526 antibody|Glutamate[NMDA] receptor subunit epsilon 2 antibody|Glutamate[NMDA] receptor subunit epsilon-2 antibody|Glutamate Receptor Ionotropic N Methyl D Aspartate 2B antibody|Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B antibody|Glutamate receptor ionotropic NMDA2B antibody|Glutamate receptor subunit epsilon 2 antibody|Glutamate receptor, ionotropic, NMDA2B(epsilon 2) antibody|GRIN 2B antibody|GRIN2B antibody|hNR 3 antibody|hNR3 antibody|MGC142178 antibody|MGC142180 antibody|N methyl D asparate receptor channel subunit epsilon 2 antibody|N METHYL D ASPARTATE RECEPTOR CHANNEL SUBUNIT EPSILON 2 antibody|N methyl D aspartate receptor subtype 2B antibody|N methyl D aspartate receptor subunit 2B antibody|N methyl D aspartate receptor subunit 3 antibody|N-methyl D-aspartate receptor subtype 2B antibody|N-methyl-D-aspartate receptor subunit 3 antibody|NMDA NR2B antibody|NMDA R2B antibody|Nmdar2b antibody|NMDE2 antibody|NMDE2_HUMAN antibody|NME2 antibody|NR2B antibody|NR3 antibody
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Uniprot ID
Q13224
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
