NAK Antibody

• Catalog number
  PA2117
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  NAK
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human NAK(577-590aa YNEEQIHKFDKQKL), identical to the related rat and mouse sequences.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the NAK Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The NAK Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Serine/threonine-protein kinase TBK1, also called TANK-binding kinase 1 or NF-kappa-B-activating kinase is an enzyme that in humans is encoded by the TBK1 gene. The gene was assigned to human chromosome 12q14.2. Serine/threonine kinase plays an essential role in regulating inflammatory responses to foreign agents. TBK1 and NF-kappa-B signaling are essential in KRAS mutant tumors, and established a general approach for the rational identification of codependent pathways in cancer.
• Related articles
  1. Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C., Frohling, S., Chan, E. M., and 23 others. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462: 108-112, 2009. 2. Chien, Y., Kim, S., Bumeister, R., Loo, Y.-M., Kwon, S. W., Johnson, C. L., Balakireva, M. G., Romeo, Y., Kopelovich, L., Gale, M., Jr., Yeaman, C., Camonis, J. H., Zhao, Y., White, M. A. RalB GTPase-mediated activation of the I-kappa-B family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127: 157-170, 2006. 3. Fingert, J. H., Robin, A. L., Stone, J. L., Roos, B. R., Davis, L. K., Scheetz, T. E., Bennett, S. R., Wassink, T. H., Kwon, Y. H., Alward, W. L. M., Mullins, R. F., Sheffield, V. C., Stone, E. M. Copy number variations on chromosome 12q14 in patients with normal tension glaucoma. Hum. Molec. Genet. 20: 2482-2494, 2011. 4. Fujita, F., Taniguchi, Y., Kato, T., Narita, Y., Furuya, A., Ogawa, T., Sakurai, H., Joh, T., Itoh, M., Delhase, M., Karin, M., Nakanishi, M. Identification of NAP1, a regulatory subunit of I-kappa-B kinase-related kinases that potentiates NF-kappa-B signaling. Molec. Cell. Biol. 23: 7780-7793, 2003.
• Gene Name
  TBK1
• Protein Name
  Serine/threonine-protein kinase TBK1
• Gene Full Name
  TANK-binding kinase 1
• Synonyms
  EC 2.7.11.1 antibody|FLJ11330 antibody|NAK antibody|NF kappa B activating kinase antibody|NF kB activating kinase antibody|NF-kappa-B-activating kinase antibody|Serine/threonine protein kinase TBK 1 antibody|Serine/threonine protein kinase TBK1 antibody|Serine/threonine-protein kinase TBK1 antibody|T2K antibody|TANK antibody|TANK binding kinase 1 antibody|TANK-binding kinase 1 antibody|TBK 1 antibody|Tbk1 antibody|TBK1_HUMAN antibody|TRAF 2 antibody|TRAF2 antibody
• Uniprot ID
  Q9UHD2
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NAK  
• Gene symbol
  TBK1, NR4A1
• Short name
  NAK Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  NAK (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11584
• Gene
  TBK1
• Long gene name
  TANK binding kinase 1
• Synonyms gene name
  • TANK-binding kinase 1
• Synonyms
  • NAK
• GenBank acession
  • AF191838
• Locus
  12q14.2
• Discovery year
  2000-06-08
• Entrez gene record
  29110
• Pubmed identfication
  • 10581243
  • 10783893
• RefSeq identity
  • NM_013254
• Classification
  • I kappa B kinases
• VEGA ID
  OTTHUMG00000168796
• Locus Specific Databases
  • LRG_1306

Gene info

• Identity
  HGNC:7980
• Gene
  NR4A1
• Long gene name
  nuclear receptor subfamily 4 group A member 1
• Synonyms gene
  • HMR
  • GFRP1
• Synonyms gene name
  • nuclear receptor subfamily 4, group A, member 1
• Synonyms
  • TR3
  • N10
  • NAK-1
  • NGFIB
  • NUR77
• GenBank acession
  • L13740
• Locus
  12q13.13
• Discovery year
  1990-09-10
• Entrez gene record
  3164
• Pubmed identfication
  • 2626032
• Classification
  • Nuclear receptor subfamily 4 group A
• VEGA ID
  OTTHUMG00000150393

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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