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Target antigen
MMP24
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human MMP24(208-225aa YHEIKSDRKEADIMIFFA), identical to the related mouse and rat sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the MMP24 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The MMP24 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Matrix metalloproteinase-24, also known as MT5MMP or MMP25, is an enzyme that in humans is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase(MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP(MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. This gene may be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.
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Related articles
1. Kinoh, H., Hayashita, H., Kajita, M., Okada, A., Seiki, M. Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-q12, respectively, by radiation hybrid and in situ hybridization. Cytogenet. Cell Genet. 87: 97-98, 1999. 2. Llano, E., Pendas, A. M., Freije, J. P., Nakano, A., Knauper, V., Murphy, G., Lopez-Otin, C. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase A overexpressed in brain tumors. Cancer Res. 59: 2570-2576, 1999.
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Gene Name
MMP24
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Protein Name
Matrix metalloproteinase-24
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Gene Full Name
matrix metallopeptidase 24(membrane-inserted)
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Synonyms
Matrix metallopeptidase 24(membrane inserted) antibody|Matrix metallopeptidase 24 antibody|Membrane type 5 matrix metalloproteinase antibody|Membrane type matrix metalloproteinase 5 antibody|Membrane-type matrix metalloproteinase 5 antibody|Membrane-type-5 matrix metalloproteinase antibody|MMP 24 antibody|MMP 25 antibody|MMP-24 antibody|Mmp24 antibody|MMP24_HUMAN antibody|MMP25 antibody|MT MMP5 antibody|MT-MMP 5 antibody|MT5 MMP antibody|MT5-MMP antibody|MT5MMP antibody|MTMMP5 antibody|Processed matrix metalloproteinase-24 antibody
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Uniprot ID
Q9Y5R2
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
