LOX 1 Antibody

• Catalog number
  PA1832
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  LOX 1
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat Predicted to work with: mouse
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human LOX 1(1-16aa MTFDDLKIQTVKDQPD).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the LOX 1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The LOX 1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  OLR1(oxidized low density lipoprotein(lectin-like) receptor 1) also called CLEC8A, LOX-1, SCARE1, is a receptor protein which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein(OxLDL). The OLR1 gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on LOX1 expression, but incubation with OxLDL resulted in a dose-dependent increase in LOX1 mRNA and protein expression; however, very high concentrations of OxLDL caused a decrease in OxLDL expression, perhaps indicating toxic effects on endothelial cells. LOX1 was also expressed in macrophages, but not in vascular smooth muscle cells. The findings suggested a role for LOX1 in the pathophysiology of atherosclerotic cardiovascular disease. LOX1 expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX1 within the posterior segments of normal eyes. LOX1 plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.
• Related articles
  1. Aoyama, T., Sawamura, T., Furutani, Y., Matsuoka, R., Yoshida, M. C., Fujiwara, H., Masaki, T. Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene. Biochem. J. 339: 177-184, 1999. 2. Delneste, Y., Magistrelli, G., Gauchat, J.-F., Haeuw, J.-F., Aubry, J.-P., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J.-Y., Jeannin, P. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 17: 353-362, 2002. 3. Luedecking-Zimmer, E., DeKosky, S. T., Chen, Q., Barmada, M. M., Kamboh, M. I. Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12. Hum. Genet. 111: 443-451, 2002.
• Gene Name
  OLR1
• Protein Name
  Oxidized low-density lipoprotein receptor 1(Ox-LDL receptor 1)
• Gene Full Name
  oxidized low density lipoprotein(lectin-like) receptor 1
• Synonyms
  C-type lectin domain family 8 member A antibody|CLEC8A antibody|hLOX 1 antibody|hLOX-1 antibody|Lectin like oxidized LDL receptor 1 antibody|Lectin like oxLDL receptor 1 antibody|Lectin type oxidized LDL receptor 1 antibody|Lectin-like oxidized LDL receptor 1 antibody|Lectin-like oxLDL receptor 1 antibody|Lectin-type oxidized LDL receptor 1 antibody|LOX-1 antibody|LOXIN antibody|Olr1 antibody|OLR1_HUMAN antibody|Ox LDL receptor 1 antibody|Ox-LDL receptor 1 antibody|Oxidised low density lipoprotein(lectin like) receptor 1 antibody|Oxidized low density lipoprotein receptor 1 antibody|Oxidized low density lipoprotein receptor 1 soluble form antibody|Oxidized low-density lipoprotein receptor 1 antibody|SCARE1 antibody|Scavenger receptor class E, member 1 antibody|SLOX1 antibody|soluble form antibody|SR-EI antibody
• Uniprot ID
  P78380
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LOX  
• Gene symbol
  LOX, ALOX5, ALOX12B, ALOX12, ALOX15, ALOX15B, ALOXE3, OLR1
• Short name
  LOX 1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  LOX 1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6664
• Gene
  LOX
• Long gene name
  lysyl oxidase
• Synonyms name
  • protein-lysine 6-oxidase
• Locus
  5q23.1
• Discovery year
  1986-01-01
• Entrez gene record
  4015
• Pubmed identfication
  • 1685472
• VEGA ID
  OTTHUMG00000128914
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:435
• Gene
  ALOX5
• Long gene name
  arachidonate 5-lipoxygenase
• Synonyms
  • 5-LOX
• GenBank acession
  • J03571
• Locus
  10q11.21
• Discovery year
  1992-07-10
• Entrez gene record
  240
• Pubmed identfication
  • 2565035
• Classification
  • Arachidonate lipoxygenases
• VEGA ID
  OTTHUMG00000018081

Gene info

• Identity
  HGNC:430
• Gene
  ALOX12B
• Long gene name
  arachidonate 12-lipoxygenase, 12R type
• Synonyms
  • 12R-LOX
• Synonyms name
  • 12R-lipoxygenase
• GenBank acession
  • AF038461
• Locus
  17p13.1
• Discovery year
  1998-07-22
• Entrez gene record
  242
• Pubmed identfication
  • 9618483
• Classification
  • Arachidonate lipoxygenases
• VEGA ID
  OTTHUMG00000108180
• Locus Specific Databases
  • LRG_1264

Gene info

• Identity
  HGNC:429
• Gene
  ALOX12
• Long gene name
  arachidonate 12-lipoxygenase, 12S type
• Synonyms gene name
  • arachidonate 12-lipoxygenase
• Synonyms
  • 12S-LOX
• Synonyms name
  • platelet 12-LOX
  • Arachidonate 12-lipoxygenase, 12S-type
• GenBank acession
  • M35418
• Locus
  17p13.1
• Discovery year
  1991-08-07
• Entrez gene record
  239
• Pubmed identfication
  • 1570320
• Classification
  • Arachidonate lipoxygenases
• VEGA ID
  OTTHUMG00000102088

Gene info

• Identity
  HGNC:433
• Gene
  ALOX15
• Long gene name
  arachidonate 15-lipoxygenase
• Synonyms
  • 15-LOX-1
• GenBank acession
  • M23892
• Locus
  17p13.2
• Discovery year
  1992-11-20
• Entrez gene record
  246
• Pubmed identfication
  • 1570320
• Classification
  • Arachidonate lipoxygenases
• VEGA ID
  OTTHUMG00000090746

Gene info

• Identity
  HGNC:434
• Gene
  ALOX15B
• Long gene name
  arachidonate 15-lipoxygenase type B
• Synonyms gene name
  • arachidonate 15-lipoxygenase, second type
• Synonyms
  • 15-LOX-2
• GenBank acession
  • U78294
• Locus
  17p13.1
• Discovery year
  1998-07-22
• Entrez gene record
  247
• Pubmed identfication
  • 9177185
• Classification
  • Arachidonate lipoxygenases
• VEGA ID
  OTTHUMG00000108181

Gene info

• Identity
  HGNC:13743
• Gene
  ALOXE3
• Long gene name
  arachidonate lipoxygenase 3
• Synonyms
  • eLOX3
  • E-LOX
• Synonyms name
  • Epidermal lipoxygenase-3
  • hydroperoxide isomerase
• GenBank acession
  • AJ269499
• Locus
  17p13.1
• Discovery year
  2000-11-29
• Entrez gene record
  59344
• Pubmed identfication
  • 12881489
• Classification
  • Arachidonate lipoxygenases
• VEGA ID
  OTTHUMG00000108179

Gene info

• Identity
  HGNC:8133
• Gene
  OLR1
• Long gene name
  oxidized low density lipoprotein receptor 1
• Synonyms gene name
  • oxidised low density lipoprotein (lectin-like) receptor 1
• Synonyms
  • LOX-1
  • SCARE1
  • CLEC8A
• GenBank acession
  • D89050
• Locus
  12p13.2
• Discovery year
  1998-01-16
• Entrez gene record
  4973
• Pubmed identfication
  • 9763655
• RefSeq identity
  • NM_002543
• Classification
  • C-type lectin domain containing
  • Scavenger receptors
• VEGA ID
  OTTHUMG00000168527

MeSH Data

• Name
  Cloning, Molecular
• Concept
  Scope note: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
• Tree numbers
  • E05.393.220
• Qualifiers
  drug effects, methods, radiation effects

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