-
Target antigen
Kallikrein 5
-
Clonality
Polyclonal antibody
-
Clone
Polyclonal antibody
-
Raised in
rabbit
-
Type of the antibody
IgG polyclonal antibody
-
Product form
freeze-dried
-
Reacts with species
Human. No cross reactivity with other proteins.
-
Analyses
WB,IHC-P
-
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 5(278-293aa NLCEFVKWIKDTMNSN), different from the related rat sequence by three amino acids.
-
Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
-
Purification
Immunogen affinity purified.
-
Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
-
Storage condtions
Keep the Kallikrein 5 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
-
Tips
The Kallikrein 5 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
-
Background
KLK5(Kallikrein-related peptidase 5), formerly known as stratum corneum tryptic enzyme(SCTE) or KLKL2, is a serine protease expressed in the epidermis. The KLK5 gene is one of the fifteen kallikrein subfamily members which is located on 19q13.41. KLK5 has been suggested to regulate cell shedding in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. The KLK5 gene contains 5 coding exons spanning 9.3. KLK5 expression is upregulated in a breast cancer cell line in the presence of estrogens and progestins and is associated with more aggressive forms of epithelial ovarian carcinoma.
-
Related articles
1. Brattsand, M., Egelrud, T. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J. Biol. Chem. 274: 30033-30040, 1999. 2. Elliott, M. B., Irwin, D. M., Diamandis, E. P. In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88: 591-599, 2006. 3. Gan, L., Lee, I., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B., Wang, K. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257: 119-130, 2000.
-
Gene Name
KLK5
-
Protein Name
Kallikrein 1-related peptidase b5
-
Gene Full Name
kallikrein-related peptidase 5
-
Synonyms
HK5 antibody|Kallikrein 5 antibody|Kallikrein L2 antibody|Kallikrein Like 2 antibody|Kallikrein like protein 2 antibody|Kallikrein related peptidase 5 antibody|Kallikrein-5 antibody|Kallikrein-like protein 2 antibody|Kallikrein5 antibody|KLK 5 antibody|KLK L2 antibody|KLK-L2 antibody|KLK5 antibody|KLK5_HUMAN antibody|KLKL 2 antibody|KLKL2 antibody|SCTE antibody|Stratum Corneum Tryptic Enzyme antibody|UNQ570/PRO1132 antibody
-
Uniprot ID
Q9D140
-
Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
