Iduronate 2 sulfatase Antibody

• Catalog number
  PA1917
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Iduronate 2 sulfatase
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human Iduronate 2 sulfatase(430-448aa ELCREGKNLLKHFRFRDLE).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Iduronate 2 sulfatase Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Iduronate 2 sulfatase Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  IDS(Iduronate-2-sulfatase) is a sulfatase enzyme associated with Hunter syndrome. Iduronate 2-sulfatase is involved in the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. Wilson et al.(1991) used an IDS cDNA clone to localize the gene to Xq28, distal to the fragile X site. Faust et al.(1992) and Daniele et al.(1993) demonstrated that the homologous Ids gene in the mouse occupies the same position on the X chromosome in relation to the FMR1, F9, and GABRA3 genes. Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase.
• Related articles
  1. Daniele, A., Faust, C. J., Herman, G. E., Di Natale, P., Ballabio, A. Cloning and characterization of the cDNA for the murine iduronate sulfatase gene. Genomics 16: 755-757, 1993. 2. Faust, C. J., Verkerk, A. J. M. H., Wilson, P. J., Morris, C. P., Hopwood, J. J., Oostra, B. A., Herman, G. E. Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes. Genomics 12: 814-817, 1992. 3. Wilson, P. J., Suthers, G. K., Callen, D. F., Baker, E., Nelson, P. V., Cooper, A., Wraith, J. E., Sutherland, G. R., Morris, C. P., Hopwood, J. J. Frequent deletions at Xq28 indicate genetic heterogeneity in Hunter syndrome. Hum. Genet. 86: 505-508, 1991.
• Gene Name
  IDS
• Protein Name
  Iduronate 2-sulfatase
• Gene Full Name
  iduronate 2-sulfatase
• Synonyms
  Alpha L iduronate sulfate sulfatase antibody|Alpha-L-iduronate sulfate sulfatase antibody|AW214631 antibody|Ids antibody|IDS_HUMAN antibody|Iduronate 2 sulfatase 14 kDa chain antibody|Iduronate 2 sulfatase 42 kDa chain antibody|Iduronate 2 sulfatase antibody|Iduronate 2-sulfatase 14 kDa chain antibody|Iduronate sulfatase antibody|Idursulfase antibody|MPS2 antibody|RP23-29M4.1 antibody|SIDS antibody
• Uniprot ID
  P22304
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Iduronate   sulfatase  
• Gene symbol
  IDSP1, IDS
• Short name
  Iduronate 2 sulfatase Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Iduronate 2 sulfatase (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:5390
• Gene
  IDSP1
• Long gene name
  iduronate 2-sulfatase pseudogene 1
• Synonyms
  • IDS2
• GenBank acession
  • L36846
• Locus
  Xq28
• Discovery year
  1995-07-11
• Entrez gene record
  3424
• Pubmed identfication
  • 7814022
• RefSeq identity
  • NG_001149
• VEGA ID
  OTTHUMG00000022620

Gene info

• Identity
  HGNC:5389
• Gene
  IDS
• Long gene name
  iduronate 2-sulfatase
• Synonyms gene
  • SIDS
• Synonyms
  • ID2S
• Synonyms name
  • Hunter syndrome
• GenBank acession
  • M58342
• Locus
  Xq28
• Discovery year
  2001-06-22
• Entrez gene record
  3423
• Classification
  • Sulfatases
• VEGA ID
  OTTHUMG00000022615
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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