Huntingtin Antibody

• Catalog number
  PA2268
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Huntingtin
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human Huntingtin(3106-3121aa ELDRRAFQSVLEVVAA), different from the related mouse and rat sequences by two amino acids.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Huntingtin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Huntingtin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  The huntingtin gene, also called HTT or HD(Huntington disease) gene, is the IT15("interesting transcript 15") gene which codes for a protein called the huntingtin protein. It is mapped to 4p16.3. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor(BDNF) at the transcription level, and this gene is required for normal development. The HTT protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. What's more, wildtype HTT may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.
• Related articles
  1. Kegel, K. B., Meloni, A. R., Yi, Y., Kim, Y. J., Doyle, E., Cuiffo, B. G., Sapp, E., Wang, Y., Qin, Z.-H., Chen, J. D., Nevins, J. R., Aronin, N., DiFiglia, M. Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. J. Biol. Chem. 277: 7466-7476, 2002. 2. The Huntington's Disease Collaborative Research Group (March 1993). "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes". Cell 72 (6): 971–83. 3. Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E (July 2001). "Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease". Science 293(5529): 493–8.
• Gene Name
  HTT
• Protein Name
  Huntingtin
• Gene Full Name
  huntingtin
• Synonyms
  AI256365 antibody|C430023I11Rik antibody|HD antibody|HD protein antibody|HDH antibody|HTT antibody|Huntingtin antibody|HUNTINGTON CHOREA antibody|Huntington disease protein antibody|IT 15 antibody|IT15 antibody|OTTMUSP00000026909 antibody|ZHD antibody
• Uniprot ID
  P42858
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Huntingtin  
• Gene symbol
  HTT, HAP1, HIP1
• Short name
  Huntingtin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Huntingtin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4851
• Gene
  HTT
• Long gene name
  huntingtin
• Synonyms gene
  • HD
• Synonyms gene name
  • huntingtin (Huntington disease)
• Synonyms
  • IT15
• GenBank acession
  • L12392
• Locus
  4p16.3
• Discovery year
  1986-01-01
• Entrez gene record
  3064
• Pubmed identfication
  • 8458085
• RefSeq identity
  • NM_002111
• Classification
  • Receptor ligands
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000159916
• Locus Specific Databases
  • LRG_763

Gene info

• Identity
  HGNC:4812
• Gene
  HAP1
• Long gene name
  huntingtin associated protein 1
• Synonyms gene
  • HAP2
• Synonyms gene name
  • huntingtin-associated protein 1
• Synonyms
  • HLP
  • hHLP1
  • HIP5
• Synonyms name
  • neuroan 1
• GenBank acession
  • AF040723
• Locus
  17q21.2
• Discovery year
  1999-04-28
• Entrez gene record
  9001
• Pubmed identfication
  • 7477378
  • 9668110
• RefSeq identity
  • NM_003949
• VEGA ID
  OTTHUMG00000133498

Gene info

• Identity
  HGNC:4913
• Gene
  HIP1
• Long gene name
  huntingtin interacting protein 1
• Synonyms
  • ILWEQ
• GenBank acession
  • AF052288
• Locus
  7q11.23
• Discovery year
  1997-08-28
• Entrez gene record
  3092
• Pubmed identfication
  • 9140394
  • 9147654
• RefSeq identity
  • NM_005338
• VEGA ID
  OTTHUMG00000156050

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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