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Target antigen
GRO alpha
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human GRO alpha(99-107aa KMLNSDKSN).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the GRO alpha Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The GRO alpha Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
CXCL1(Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROalpha, KC, Neutrophil-activating protein 3(NAP-3) and melanoma growth stimulating activity, alpha(MSGA-alpha). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis signature genes identified, several, including CXCL1, were functionally validated.
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Related articles
1. Anisowicz, A., Zajchowski, D., Stenman, G., Sager, R. Functional diversity of GRO gene expression in human fibroblasts and mammary epithelial cells. Proc. Nat. Acad. Sci. 85: 9645-9649, 1988. 2. Horuk, R., Yansura, D. G., Reilly, D., Spencer, S., Bourell, J., Henzel, W., Rice, G., Unemori, E. Purification, receptor binding analysis, and biological characterization of human melanoma growth stimulating activity (MGSA): evidence for a novel MGSA receptor. J. Biol. Chem. 268: 541-546, 1993. 3. O'Donovan, N., Galvin, M., Morgan, J. G. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999.
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Gene Name
CXCL1
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Protein Name
Growth-regulated alpha protein
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Gene Full Name
chemokine(C-X-C motif) ligand 1(melanoma growth stimulating activity, alpha)
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Synonyms
C-X-C motif chemokine 1 antibody|Chemokine(C X C motif) ligand 1 antibody|Chemokine(C-X-C motif) ligand 1(melanoma growth stimulating activity, alpha) antibody|chemokine(C-X-C motif) ligand 1 antibody|Chemokine ligand 1 antibody|CINC-1 antibody|Cxcl 1 antibody|Cxcl1 antibody|Cytokine-induced neutrophil chemoattractant 1 antibody|Fibroblast secretory protein antibody|Fsp antibody|Gro 1 antibody|Gro A antibody|GRO alpha antibody|GRO antibody|GRO protein, alpha antibody|GRO-alpha(1-73) antibody|GRO-alpha(6-73) antibody|Gro1 antibody|GRO1 oncogene(melanoma growth stimulating activity, alpha) antibody|GRO1 oncogene(melanoma growth-stimulating activity) antibody|Gro1 oncogene antibody|GroA antibody|GROA_HUMAN antibody|Growth regulated protein alpha antibody|Growth regulated protein GRO antibody|KC antibody|KC chemokine, mouse, homolog of antibody|Melanoma growth stimulatory activity alpha antibody|Melanoma growth stimulatory activity antibody|Melanoma growth stimulatory activity, alpha antibody|MGSA a antibody|MGSA alpha antibody|MGSA antibody|MGSA-a antibody|N51 antibody|NAP 3 antibody|NAP-3 antibody|NAP3 antibody|Neutrophil activating protein 3 antibody|Neutrophil-activating protein 3 antibody|Platelet-derived growth factor-inducible protein KC antibody|Scyb 1 antibody|SCYB1 antibody|Secretory protein N51 antibody|Small inducible cytokine subfamily B, member 1 antibody
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Uniprot ID
P09341
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Description
The GRO alpha Antibody is a α- or alpha protein sometimes glycoprotein present in blood.
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
