Gla Antibody

• Catalog number
  A01135
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Gla
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of mouse Gla (218-275aa DIQYYCNHWRNFDDVYDSWESIKNILSWTVVYQKEIVEVA), different from the related human sequence by fifteen amino acids.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Gla Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Gla Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Alpha-galactosidase is a glycoside hydrolase enzyme that encoded by the GLA gene. This gene is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.
• Related articles
  1. "Entrez Gene: GLA galactosidase, alpha". 2. Calhoun DH, Bishop DF, Bernstein HS, Quinn M, Hantzopoulos P, Desnick RJ (1985). "Fabry disease: isolation of a cDNA clone encoding human alpha-galactosidase A". Proceedings of the National Academy of Sciences of the United States of America. 82 (21): 7364–8. 3. Keating GM (October 2012). "Agalsidase alfa: a review of its use in the management of Fabry disease". BioDrugs. 26 (5): 335–54.
• Gene Name
  Gla
• Protein Name
  Alpha-galactosidase A
• Gene Full Name
  galactosidase, alpha
• Synonyms
  Ags | Agalsidase alfa | Alpha D galactosidase A | Alpha gal A | GALA | Galactosidase, alpha | GLA | GLA protein | Melibiase | P06280
• Uniprot ID
  P51569
• Entrez GeneID
  11605
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Gla  
• Gene symbol
  PRRG1, GLA, PRRG3
• Short name
  Gla Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Gla (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9469
• Gene
  PRRG1
• Long gene name
  proline rich and Gla domain 1
• Synonyms gene name
  • proline-rich Gla (G-carboxyglutamic acid) polypeptide 1
• Synonyms
  • PRGP1
• GenBank acession
  • AF009242
• Locus
  Xp21.1
• Discovery year
  1997-10-16
• Entrez gene record
  5638
• Pubmed identfication
  • 9256434
• RefSeq identity
  • NM_000950
• Classification
  • Proline rich and Gla domain containing
• VEGA ID
  OTTHUMG00000021360
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:4296
• Gene
  GLA
• Long gene name
  galactosidase alpha
• Synonyms
  • GALA
• GenBank acession
  • X16889
• Locus
  Xq22.1
• Discovery year
  2001-06-22
• Entrez gene record
  2717
• Pubmed identfication
  • 6323102
  • 3014515
• Classification
  • Galactosidases alpha
• VEGA ID
  OTTHUMG00000022026
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_672

Gene info

• Identity
  HGNC:30798
• Gene
  PRRG3
• Long gene name
  proline rich and Gla domain 3
• Synonyms gene name
  • proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
• Synonyms
  • TMG3
• GenBank acession
  • AK074574
• Locus
  Xq28
• Discovery year
  2004-09-01
• Entrez gene record
  79057
• Pubmed identfication
  • 11171957
• RefSeq identity
  • NM_024082
• Classification
  • Proline rich and Gla domain containing
• VEGA ID
  OTTHUMG00000024170
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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