Gelsolin Antibody

• Catalog number
  PB9209
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Gelsolin
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  Human. No cross reactivity with other proteins.
• Analyses
  WB,IHC-P
• Immunogen
  E.coli-derived human Gelsolin recombinant protein (Position: E580-A782). Human Gelsolin shares 94% and 95% amino acid (aa) sequences identity with mouse and rat Gelsolin, respectively.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Gelsolin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Gelsolin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Gelsolin, also known as GNS or brevin, is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. It is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. Gelsolin may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.
• Related articles
  1. Kamada, S., Kusano, H., Fujita, H., Ohtsu, M., Koya, R. C., Kuzumaki, N., Tsujimoto, Y. A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin. Proc. Nat. Acad. Sci. 95: 8532-8537, 1998. 2. Kim, J., Lee, J. E., Heynen-Genel, S., Suyama, E., Ono, K., Lee, K., Ideker, T., Aza-Blanc, P., Gleeson, J. G. Functional genomic screen for modulators of ciliogenesis and cilium length. Nature 464: 1048-1051, 2010. 3. Vasconcellos, C. A., Allen, P. G., Wohl, M. E., Drazen, J. M., Janmey, P. A., Stossel, T. P. Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science 263: 969-971, 1994.
• Gene Name
  GSN
• Protein Name
  Gelsolin
• Gene Full Name
  gelsolin
• Synonyms
  Actin depolymerizing factor antibody|Actin-depolymerizing factor antibody|ADF antibody|AGEL antibody|Brevin antibody|DKFZp313L0718 antibody|GELS_HUMAN antibody|Gelsolin antibody|GSN antibody
• Uniprot ID
  P06396
• Entrez GeneID
  2934
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Gelsolin  
• Gene symbol
  GSN, CAPG
• Short name
  Gelsolin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Gelsolin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4620
• Gene
  GSN
• Long gene name
  gelsolin
• Synonyms gene name
  • gelsolin (amyloidosis, Finnish type)
• Synonyms
  • DKFZp313L0718
• Synonyms name
  • amyloidosis, Finnish type
• GenBank acession
  • X04412
• Locus
  9q33.2
• Discovery year
  1988-07-19
• Entrez gene record
  2934
• Pubmed identfication
  • 1652889
• RefSeq identity
  • NM_000177
• Classification
  • Gelsolin/villins
• VEGA ID
  OTTHUMG00000020584

Gene info

• Identity
  HGNC:1474
• Gene
  CAPG
• Long gene name
  capping actin protein, gelsolin like
• Synonyms gene
  • AFCP
• Synonyms gene name
  • capping protein (actin filament), gelsolin-like
• Synonyms
  • MCP
• Synonyms name
  • macrophage capping protein
• GenBank acession
  • M94345
• Locus
  2p11.2
• Discovery year
  1993-12-14
• Entrez gene record
  822
• Pubmed identfication
  • 1322908
  • 12754261
• RefSeq identity
  • NM_001747
• Classification
  • Gelsolin/villins
• VEGA ID
  OTTHUMG00000130183

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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