FSTL3 Antibody

• Catalog number
  PA1915
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  FSTL3
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence in the middle region of human FSTL3(145-159aa ECELRAARCRGHPDL), different from the related rat and mouse sequences by one amino acid.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the FSTL3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The FSTL3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  FSTL3(Follistatin-Like 3) also known as FLRG or FOLLISTATIN-RELATED GENE, is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins though to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. The FSTL3 gene extends over 7 kbp and contains 5 exons. By Southern blot analysis of somatic cell hybrids and FISH, Hayette et al.(1998) localized the FSTL3 gene to chromosome 19p13. Using recombinant mouse Fstl3, Tsuchida et al.(2000) found that Fstl3bound both activin and BMP2 and had a higher affinity for activin. Overexpression of Fstl3 inhibited BMP2-induced cell signaling in a reporter assay. In addition to the translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, Hayette et al.(1998) also observed rearrangement of the FSTL3 gene in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.
• Related articles
  1. Hayette, S., Gadoux, M., Martel, S., Bertrand, S., Tigaud, I., Magaud, J.-P., Rimokh, R. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders.Oncogene 16: 2949-2954, 1998. 2. Mukherjee, A., Sidis, Y., Mahan, A., Raher, M. J., Xia, Y., Rosen, E. D., Bloch, K. D., Thomas, M. K., Schneyer, A. L. FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc. Nat. Acad. Sci. 104: 1348-1353, 2007. 3. Tsuchida, K., Arai, K. Y., Kuramoto, Y., Yamakawa, N., Hasegawa, Y., Sugino, H. Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. J. Biol. Chem. 275: 40788-40796, 2000.
• Gene Name
  FSTL3
• Protein Name
  Follistatin-related protein 3
• Gene Full Name
  follistatin-like 3(secreted glycoprotein)
• Synonyms
  FLRG antibody|follistatin-like 3 antibody|follistatin-like 3 glycoprotein antibody|Follistatin-like protein 3 antibody|Follistatin-related gene protein antibody|Follistatin-related protein 3 antibody|FSRP antibody|Fstl3 antibody|FSTL3_HUMAN antibody
• Uniprot ID
  O95633
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FSTL3  
• Gene symbol
  FSTL3
• Short name
  FSTL3 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  follistatin-like 3 (secreted glycoprotein) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  follistatin-like 3 (secreted glycoprotein), FLRG and FSRP, FSTL3 and IDBG-12738 and ENSG00000070404 and 10272, activin binding, nuclei, Fstl3 and IDBG-170833 and ENSMUSG00000020325 and 83554, FSTL3 and IDBG-645504 and ENSBTAG00000003018 and 515367

Gene info

• Identity
  HGNC:3973
• Gene
  FSTL3
• Long gene name
  follistatin like 3
• Synonyms gene name
  • follistatin-like 3 (secreted glycoprotein)
• Synonyms
  • FLRG
  • FSRP
• Synonyms name
  • follistatin-related protein
• GenBank acession
  • U76702
• Locus
  19p13.3
• Discovery year
  1999-09-07
• Entrez gene record
  10272
• Pubmed identfication
  • 9671416
  • 15527507
• RefSeq identity
  • NM_005860
• VEGA ID
  OTTHUMG00000180593

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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