Filaggrin Antibody

• Catalog number
  PB9870
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Filaggrin
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat
• Analyses
  WB,IHC-P
• Immunogen
  E. coli-derived human Filaggrin recombinant protein (Position: M1-R261).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Filaggrin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Filaggrin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  In humans, profillagrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
• Related articles
  1. Kypriotou, Magdalini; Huber, Marcel; Hohl, Daniel (September 2012)."The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family". Experimental Dermatology 21 (9): 643–649. 2. Markova, NG; Marekov, LN; Chipev, CC; Gan, SQ; Idler, WW; Steinert, PM (January 1993). "Profilaggrin is a major epidermal calcium-binding protein.". Molecular and Cellular Biology 13 (1): 613–25.
• Gene Name
  FLG
• Protein Name
  Filaggrin
• Gene Full Name
  filaggrin
• Synonyms
  Epidermal filaggrin antibody|FILA_HUMAN antibody|Filaggrin antibody|Filaggrin precursor antibody|Fillagrin antibody|FLG antibody| Profilaggrin antibody
• Uniprot ID
  P20930
• Entrez GeneID
  2312
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Filaggrin  
• Gene symbol
  FLG2, FLG, HRNR
• Short name
  Filaggrin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Filaggrin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:33276
• Gene
  FLG2
• Long gene name
  filaggrin 2
• Synonyms gene name
  • filaggrin family member 2
• Synonyms
  • IFPS
• Synonyms name
  • ifapsoriasin
• GenBank acession
  • AY827490
• Locus
  1q21.3
• Discovery year
  2007-08-21
• Entrez gene record
  388698
• Pubmed identfication
  • 19384417
• RefSeq identity
  • NM_001014342
• Classification
  • S100 fused type protein family
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000012245

Gene info

• Identity
  HGNC:3748
• Gene
  FLG
• Long gene name
  filaggrin
• Locus
  1q21.3
• Discovery year
  1989-10-18
• Entrez gene record
  2312
• Pubmed identfication
  • 2740331
  • 2248957
  • 16444271
• RefSeq identity
  • NM_002016
• Classification
  • S100 fused type protein family
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000012202
• Locus Specific Databases
  • LRG_1028

Gene info

• Identity
  HGNC:20846
• Gene
  HRNR
• Long gene name
  hornerin
• Synonyms
  • S100a18
  • S100A16
  • FLG3
• Synonyms name
  • filaggrin family member 3
• GenBank acession
  • AB104446
• Locus
  1q21.3
• Discovery year
  2004-10-05
• Entrez gene record
  388697
• Pubmed identfication
  • 15507446
• RefSeq identity
  • NM_001009931
• Classification
  • S100 fused type protein family
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000012243

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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