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Target antigen
FGF8
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human FGF8(163-185aa FMKRLPRGHHTTEQSLRFEFLNY), identical to the related rat and mouse sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the FGF8 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The FGF8 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Fibroblast growth factor 8(androgen-induced), also known as FGF8 or AIGF, is a human gene which maps to 10q24. The protein encoded by this gene are secreted proteins that interact with FGF tyrosine kinase receptors to mediate growth and development. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The temporal and spatial patterns of this gene expression suggest that FGF8 is involved in gastrulation, regionalization of the brain, and organogenesis of the limb and face as an embryonic epithelial factor. The adult expression of FGF8 is restricted to gonads, including testes and ovaries. FGF8 stimulated growth of human prostate carcinoma cells and mouse fibroblasts and mammary carcinoma cells in a dose-dependent manner. It also may play an important role in growth and patterning of limbs, face, and central nervous system. FGF8 is expressed in increased levels in breast cancer and in lactating human breast; it was also detected in human milk. A survey of other normal tissues showed that FGF8 is expressed in the proliferative cells of the skin and epithelial cells in colon, ovary, fallopian tube, and uterus.
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Related articles
1. Tanaka, A.; Miyamoto, K.; Matsuo, H.; Matsumoto, K.; Yoshida, H. : Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties. FEBS Lett. 363: 226-230, 1995. 2. Yoshiura, K.; Leysens, N. J.; Chang, J.; Ward, D.; Murray, J. C.; Muenke, M. : Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes. Am. J. Med. Genet. 72: 354-362, 1997. 3. Zammit, C.; Coope, R.; Gomm, J. J.; Shousha, S.; Johnston, C. L.; Coombes, R. C. : Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer. Brit. J. Cancer 86: 1097-1103, 2002.
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Gene Name
FGF8
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Protein Name
Fibroblast growth factor 8(FGF-8)
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Gene Full Name
fibroblast growth factor 8(androgen-induced)
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Synonyms
AIGF antibody|Androgen induced growth factor antibody|Androgen-induced growth factor antibody|FGF 8 antibody|FGF-8 antibody|FGF8 antibody|FGF8_HUMAN antibody|Fibroblast growth factor 8(androgen induced) antibody|Fibroblast growth factor 8 antibody|Fibroblast growth factor 8 precursor antibody|HBGF 8 antibody|HBGF-8 antibody|HBGF8 antibody|Heparin-binding growth factor 8 antibody
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Uniprot ID
P55075
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
