ErbB 2 Antibody

• Catalog number
  A00010-2
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  ErbB 2
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 2 (29-64aa TDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTY), identical to the related mouse and rat sequences.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the ErbB 2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The ErbB 2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. And it is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
• Related articles
  1. Barh D, Gunduz M (2015-01-22). Noninvasive Molecular Markers in Gynecologic Cancers. CRC Press. p. 427. 2. Mitri Z, Constantine T, O'Regan R (2012). "The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy". Chemotherapy Research and Practice. 2012: 743193.
• Gene Name
  ERBB2
• Protein Name
  Receptor tyrosine-protein kinase erbB-2
• Gene Full Name
  erb-b2 receptor tyrosine kinase 2
• Synonyms
  C erb B2/neu protein | Cerb B2/neu protein | CD340 | CD340 antigen | CerbB2 | ERBB2 | HER 2 | HER 2/NEU | HER2 | Herstatin | MLN19 | MLN 19 | NEU | NGL | p185erbB2 | TKR1 | P04626
• Uniprot ID
  P04626
• Entrez GeneID
  2064
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ErbB  
• Gene symbol
  NRG2, MIR7112-2, MIR3690-2
• Short name
  ErbB 2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  ErbB 2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7998
• Gene
  NRG2
• Long gene name
  neuregulin 2
• Synonyms
  • Don-1
  • NTAK
  • HRG2
• Synonyms name
  • neural- and thymus-derived activator for ErbB kinases
  • divergent of neuregulin-1
• Locus
  5q31.2
• Discovery year
  1999-03-19
• Entrez gene record
  9542
• Pubmed identfication
  • 9168114
  • 9168115
• RefSeq identity
  • NM_013982
• Classification
  • Neuregulins
  • I-set domain containing
• VEGA ID
  OTTHUMG00000129241

Gene info

• Identity
  HGNC:50246
• Gene
  MIR7112-2
• Long gene name
  ERBB receptor feedback inhibitor 1
• Synonyms
  • MIG-6
  • GENE-33
  • RALT
  • [HGNC:50149](/data/gene-symbol-report/#!/hgnc_id/HGNC:50149)
  • ERRFI1
• GenBank acession
  • BC025337
• Locus
  1p36.23
• Discovery year
  2005-08-23
• Entrez gene record
  54206
• Pubmed identfication
  • 10749885
  • 2780291
  • 12226756
  • 11003669
• RefSeq identity
  • NM_018948
• VEGA ID
  OTTHUMG00000001221

Gene info

• Identity
  HGNC:50218
• Gene
  MIR3690-2
• Long gene name
  ERBB receptor feedback inhibitor 1
• Synonyms
  • MIG-6
  • GENE-33
  • RALT
  • [HGNC:38967](/data/gene-symbol-report/#!/hgnc_id/HGNC:38967)
  • ERRFI1
• GenBank acession
  • BC025337
• Locus
  1p36.23
• Discovery year
  2005-08-23
• Entrez gene record
  54206
• Pubmed identfication
  • 10749885
  • 2780291
  • 12226756
  • 11003669
• RefSeq identity
  • NM_018948
• VEGA ID
  OTTHUMG00000001221

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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