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Target antigen
Eph receptor A1
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat Predicted to work with: mouse
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Eph receptor A1(963-976aa HQKRILCSIQGFKD), identical to the related rat and mouse sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Eph receptor A1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Eph receptor A1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
EPHA1, EPH receptor A1, is a protein that in humans is encoded by the EPHA1 gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The EPHA1 gene is mapped to 7q34-q35. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
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Related articles
1. Hattori, M., Osterfield, M., Flanagan, J. G.Regulated cleavage of a contact-mediated axon repellent.Science 289: 1360-1365, 2000. 2. Torii, M., Hashimoto-Torii, K., Levitt, P., Rakic, P.Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling.Nature 461: 524-528, 2009. Note: Erratum: Nature 462: 674 only, 2009.
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Gene Name
EPHA1
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Protein Name
Ephrin type-A receptor 1(hEpha1)
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Gene Full Name
EPH receptor A1
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Synonyms
EPH antibody|Eph tyrosine kinase 1 antibody|EphA1 antibody|Ephrin receptor Eph A1 antibody|Ephrin type A receptor 1 antibody|EPHT 1 antibody|EPHT antibody|Erythropoietin producing hepatoma amplified sequence antibody|Esk antibody|MGC163163 antibody|Oncogene EPH antibody|Soluble EPHA1 variant 1 antibody|Soluble EPHA1 variant 2 antibody|Tyrosine protein kinase receptor EPH antibody
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Uniprot ID
P21709
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translation
anticorps
