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Target antigen
Dysadherin
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Dysadherin(165-188aa KCRQLSRLCRNRCR).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Dysadherin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Dysadherin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
FXYD5(FXYD domain-containing ion transport regulator 5), also known as Dysadherin, is a protein that in humans is encoded by the FXYD5 gene. The gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The FXYD5 gene is mapped on 19q13.12. The deduced FXYD5 protein, the largest of the 7, contains 178 amino acids and has a signal peptide. Immunoreactivity for dysadherin, localized at cell-cell boundaries, was detected in 39 of 51 papillary carcinomas and in all 31 undifferentiated carcinomas but not in the follicular carcinomas or normal thyroid tissue controls. Dysadherin expression was significantly higher in undifferentiated carcinoma than in papillary carcinoma or follicular carcinoma and showed significant negative correlation with E-cadherin expression.
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Related articles
1. Ino, Y., Gotoh, M., Sakamoto, M., Tsukagoshi, K., Hirohashi, S. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc. Nat. Acad. Sci. 99: 365-370, 2002. 2. Omasa, T., Chen, Y.-G., Mantalaris, A., Wu, J. H. D. A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1-gamma-1/PLM/MAT8 family of transmembrane proteins. Biochim. Biophys. Acta 1517: 307-310, 2001. 3. Sweadner, K. J., Rael, E. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics 68: 41-56, 2000.
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Gene Name
FXYD5
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Protein Name
FXYD domain-containing ion transport regulator 5
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Gene Full Name
FXYD domain containing ion transport regulator 5
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Synonyms
Dysad antibody|Dysadherin antibody|FXYD 5 antibody|FXYD domain containing ion transport regulator 5 antibody|FXYD domain-containing ion transport regulator 5 antibody|Fxyd5 antibody|FXYD5_HUMAN antibody|FXYD5RIC antibody|HSPC 113 antibody|HSPC113 antibody|IWU 1 antibody|IWU1 antibody|KCT 1 antibody|KCT1 antibody|Keratinocytes associated transmembrane protein 1 antibody|OIT 2 antibody|OIT2 antibody|PRO 6241 antibody|PRO6241 antibody|RIC antibody
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Uniprot ID
Q96DB9
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
