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Target antigen
DKK2
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
E.coli-derived human DKK2 recombinant protein (Position: K34-I259). Human DKK2 shares 96% amino acid (aa) sequence identity with mouse DKK2.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the DKK2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The DKK2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene. This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).
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Related articles
1. "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)". 2. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA (Dec 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene 238 (2): 301–13. 3. Wu W, Glinka A, Delius H, Niehrs C (2001). "Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.". Curr. Biol. 10 (24): 1611–4.
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Gene Name
DKK2
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Protein Name
Dickkopf-related protein 2
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Gene Full Name
dickkopf WNT signaling pathway inhibitor 2
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Synonyms
Dickkopf 2 antibody|Dickkopf gene 2 antibody|Dickkopf homolog 2 antibody|Dickkopf related protein 2 antibody|Dickkopf WNT signaling pathway inhibitor 2 antibody|Dickkopf-2 antibody| Dickkopf-related protein 2 antibody|Dickkopf2 antibody|DKK 2 antibody|Dkk-2 antibody|Dkk2 antibody|DKK2_HUMAN antibody|hDkk 2 antibody|hDkk-2 antibody|hDkk2 antibody
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Uniprot ID
Q9UBU2
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Entrez GeneID
27123
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
