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Target antigen
CYLD
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat
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Analyses
WB
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Immunogen
E.coli-derived human CYLD recombinant protein (Position: D618-K956). Human CYLD shares 97.6% and 97.9% amino acid (aa) sequence identity with mouse and rat CYLD, respectively.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the CYLD Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The CYLD Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
CYLD is localized on the long arm of chromosome 16. This gene encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Related articles
1. Hayashi M, Jono H, Shinriki S, Nakamura T, Guo J, Sueta A, Tomiguchi M, Fujiwara S, Yamamoto-Ibusuki M, Murakami K, Yamashita S, Yamamoto Y, Li JD, Iwase H, Ando Y. “Clinical significance of CYLD downregulation in breast cancer”. Breast Cancer Res Treat, 2014 Feb. 2. Vanecek T, Halbhuber Z, Kacerovska D, Martinek P, Sedivcova M, Carr RA, Slouka D, Michal M, Kazakov DV. “Large germline deletions of the CYLD gene in patients with Brooke-Spiegler syndrome and multiple familial trichoepithelioma”. Am J Dermatopathol, 2014 Nov.
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Gene Name
CYLD
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Protein Name
Ubiquitin carboxyl-terminal hydrolase CYLD
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Gene Full Name
cylindromatosis (turban tumor syndrome)
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Synonyms
BRSS antibody|CDMT antibody|Cyld antibody|CYLD gene antibody|CYLD_HUMAN antibody|CYLD1 antibody|CYLDI antibody|cylindromatosis (turban tumor syndrome) antibody|cylindromatosis 1 antibody|Deubiquitinating enzyme CYLD antibody|EAC antibody|HSPC057 antibody|KIAA0849 antibody|MFT antibody|MFT1 antibody|Probable ubiquitin carboxyl terminal hydrolase CYLD antibody|SBS antibody|TEM antibody|turban tumor syndrome antibody|Ubiquitin carboxyl-terminal hydrolase CYLD antibody|ubiquitin specific peptidase like 2 antibody|ubiquitin thioesterase CYLD antibody|Ubiquitin thiolesterase CYLD antibody|Ubiquitin-specific processing protease CYLD antibody|Ubiquitin-specific-processing protease CYLD antibody| USPL2 antibody
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Uniprot ID
Q9NQC7
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Entrez GeneID
1540
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
