Cyclophilin A Antibody

• Catalog number
  PA1447
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Cyclophilin A
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human Cyclophilin A(54-71aa HRIIPGFMCQGCDFTRHN), different from the related mouse and rat sequences by one amino acid.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Cyclophilin A Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Cyclophilin A Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Cyclophilin A(PPIA),Peptidylprolyl isomerase A,is an enzyme that in humans is encoded by the PPIA gene.Using chromosome 7 and chromosome 10 deletion hybrid panels, the PPIA coding gene is localized to 7p13-p11.2. This gene encodes a member of the peptidyl-prolyl cis-trans isomerase(PPIase) family. Cyclophilin A is a member of the immunophilin class of proteins that all possess peptidyl-prolyl cis/trans isomerase activity and are believed to be involved in protein folding and/or intracellular protein transport. Cyclophilin A binds to the Gag protein of human immunodeficiency virus type 1(HIV-1). Cyclophilin A may have an essential function in HIV-1 replication.may have an essential function in HIV-1 replication.
• Related articles
  1. Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V., Goff, S. P.Human immunodeficiency virus type 1 gag protein binds to Cyclophilin A and B.Cell 73: 1067-1078, 1993. 2. Manel, N., Hogstad, B., Wang, Y., Levy, D. E., Unutmaz, D., Littman, D. R.A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.Nature 467: 214-217, 2010. Note: Erratum: Nature 470: 424 only, 2011. 3. Willenbrink, W., Halaschek, J., Schuffenhauer, S., Kunz, J., Steinkasserer, A. Cyclophilin A, the major intracellular receptor for the immunosuppressant cyclosporin A, maps to chromosome 7p11.2-p13: four pseudogenes map to chromosomes 3, 10, 14, and 18.Genomics 28: 101-104, 1995.
• Gene Name
  PPIA
• Protein Name
  Peptidyl-prolyl cis-trans isomerase A(PPIase A)
• Gene Full Name
  peptidylprolyl isomerase A(cyclophilin A)
• Synonyms
  Cyclophilin A|Cyclosporin A-binding protein|Rotamase A
• Uniprot ID
  P62937
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cyclophilin  
• Gene symbol
  PPIA, PPIAL4A
• Short name
  Cyclophilin A Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Cyclophilin A (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9253
• Gene
  PPIA
• Long gene name
  peptidylprolyl isomerase A
• Synonyms
  • CYPA
• Synonyms name
  • cyclophilin A
• GenBank acession
  • X52851
• Locus
  7p13
• Discovery year
  1991-12-06
• Entrez gene record
  5478
• Pubmed identfication
  • 1989998
  • 2197089
• RefSeq identity
  • NM_021130
• Classification
  • Cyclophilin peptidylprolyl isomerases
• VEGA ID
  OTTHUMG00000023687

Gene info

• Identity
  HGNC:24369
• Gene
  PPIAL4A
• Long gene name
  peptidylprolyl isomerase A like 4A
• Synonyms gene
  • PPIAL4
  • PPIAL4B
• Synonyms gene name
  • peptidylprolyl isomerase A (cyclophilin A)-like 4
  • peptidylprolyl isomerase A (cyclophilin A)-like 4B
• Synonyms
  • COAS2
• GenBank acession
  • AB084917
• Locus
  1p11.2
• Discovery year
  2005-04-21
• Entrez gene record
  653505
• Pubmed identfication
  • 11948409
• RefSeq identity
  • NM_001143883
• VEGA ID
  OTTHUMG00000185015

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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