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Target antigen
Cortisol Binding Globulin
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB,IHC-P,ICC
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Cortisol Binding Globulin(102-120aa ETEIHQGFQHLHQLFAKSD).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Cortisol Binding Globulin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Cortisol Binding Globulin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Corticosteroid-binding globulin(CBG), also known as Serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is mapped 14q32.13. This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.
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Related articles
1. Buss, C., Schuelter, U., Hesse, J., Moser, D., Phillips, D. I., Hellhammer, D., Meyer, J. Haploinsufficiency of the SEPRINA6 gene is associated with severe muscle fatigue: a de novo mutation in corticosteroid-binding globulin deficiency. J. Neural Transm. 114: 563-569, 2007. 2. Torpy, D. J., Bachmann, A. W., Grice, J. E., Fitzgerald, S. P., Phillips, P. J., Whitworth, J. A., Jackson, R. V. Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J. Clin. Endocr. Metab. 86: 3692-3700, 2001.
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Gene Name
SERPINA6
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Protein Name
Corticosteroid-binding globulin
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Gene Full Name
serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 6
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Synonyms
CBG antibody|CBG_HUMAN antibody|corticosteroid binding globulin antibody|Corticosteroid-binding globulin antibody|serine(or cysteine) proteinase inhibitor clade A(alpha 1 antiproteinase antitrypsin) member 6 antibody|Serpin A6 antibody|serpin peptidase inhibitor clade A(alpha 1 antiproteinase antitrypsin) member 6 antibody|Serpina6 antibody|Transcortin antibody
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Uniprot ID
P08185
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
