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Target antigen
Connexin 37/GJA4
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat Predicted to work with: mouse
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Analyses
WB,IHC-P,ICC
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Connexin 37(3-17aa DWGFLEKLLDQVQEH), identical to the related mouse and rat sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Connexin 37/GJA4 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Connexin 37/GJA4 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Gap junction alpha-4 protein(GJA4), also called CX37 is a protein that in humans is encoded by the GJA4 gene. This gene is mapped to 1p34.3. This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. CX37 had been shown to reflect the stage and maturity of luteinized follicles in animal studies.
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Related articles
1. Tsai, M.-Y., Lan, K.-C., Huang, K.-E., Huang, F.-J., Kung, F.-T., Chang, S.-Y. Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles. Fertil. Steril. 80: 1437-1443, 2003. 2. Wong, C. W., Christen, T., Roth, I., Chadjichristos, C. E., Deroutte, J.-P., Foglia, B. F., Chanson, M., Goodenough, D. A., Kwak, B. R. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nature Med. 12: 950-954, 2006. 3. Yamada, Y., Izawa, H., Ichihara, S., Takatsu, F., Ishihara, H., Hirayama, H., Sone, T., Tanaka, M., Yokota, M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. New Eng. J. Med. 347: 1916-1923, 2002.
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Gene Name
GJA4
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Protein Name
Gap junction alpha-4 protein
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Gene Full Name
gap junction protein, alpha 4, 37kDa
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Synonyms
Connexin 37 antibody|Connexin-37 antibody|Cx37 antibody|CXA4_HUMAN antibody|Gap junction alpha 4 protein antibody|Gap junction alpha-4 protein antibody|gap junction protein, alpha 4 37kDa(connexin 37) antibody|gap junction protein, alpha 4, 37kD(connexin 37) antibody|Gap junction protein, alpha 4, 37kDa antibody|Gja4 antibody|OTTHUMP00000004181 antibody|OTTHUMP00000004182 antibody
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Uniprot ID
P35212
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
