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Target antigen
Cdc6
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human Predicted to work with: mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Cdc6(484-503aa KLYEAYSKVCRKQQVAAVDQ).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Cdc6 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Cdc6 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Cell division control ptotein 6 homolog, also called CDC18L or CDC6, is a protein that in humans is encoded by the CDC6 gene. By analysis of somatic cell hybrids and by fluorescence in situ hybridization, this gene is mapped to 17q21.2. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. This gene is involved in the initiation of DNA replication.
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Related articles
1. Gonzalez, S., Klatt, P., Delgado, S., Conde, E., Lopez-Rios, F., Sanchez-Cespedes, M., Mendez, J., Antequera, F., Serrano, M. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440: 702-706, 2006. 2. Mimura, S., Seki, T., Tanaka, S., Diffley, J. F. X. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 431: 1118-1123, 2004. 3. Whitmire, E., Khan, B., Coue, M. Cdc6 synthesis regulates replication competence in Xenopus oocytes. Nature 419: 722-725, 2002.
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Gene Name
CDC6
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Protein Name
Cell division control protein 6 homolog
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Gene Full Name
cell division cycle 6
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Synonyms
Cdc 18L antibody|Cdc 6 antibody|CDC18(cell division cycle 18, S.pombe, homolog) like antibody|CDC18(S.pombe) antibody|Cdc18 related protein antibody|CDC18(S.pombe) antibody|Cdc18-related protein antibody|Cdc18L antibody|cdc6 antibody|CDC6 cell division cycle 6 homolog antibody|CDC6 related protein antibody|CDC6-related protein antibody|CDC6_HUMAN antibody|Cdc6p antibody|Cell Cycle Controller antibody|CELL CYCLE CONTROLLER CDC6 antibody|Cell division control protein 6 antibody|Cell division control protein 6 homolog antibody|Cell Division Cycle 18 antibody|Cell division cycle 6 homolog(S. cerevisiae) antibody|Cell division cycle 6 homolog antibody|HsCDC 6 antibody|HsCDC18 antibody|HsCDC6 antibody|p62 antibody|p62(cdc 6) antibody|p62(cdc6) antibody
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Uniprot ID
Q99741
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
