-
Target antigen
CDC5L
-
Clonality
Polyclonal antibody
-
Clone
Polyclonal antibody
-
Raised in
rabbit
-
Type of the antibody
IgG polyclonal antibody
-
Product form
freeze-dried
-
Reacts with species
human Predicted to work with: mouse
-
Analyses
WB
-
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CDC5L(782-802aa KELQHRYADLLLEKETLKSKF), different from the related rat and mouse sequences by four amino acids.
-
Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
-
Purification
Immunogen affinity purified.
-
Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
-
Storage condtions
Keep the CDC5L Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
-
Tips
The CDC5L Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
-
Background
Cell division cycle 5-like protein, also called PCDC5RP or CDC5-like, is a protein that in humans is encoded by the CDC5L gene. The CDC5L gene was mapped to chromosome 6p21 by fluorescence in situ hybridization. This DNA-binding protein involved in cell cycle control. It may act as a transcription activator. The Component of the PRP19-CDC5L complex forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The role of CDC5(Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.
-
Related articles
1. Bernstein, H. S., Coughlin, S. R. Pombe Cdc5-related protein: a putative human transcription factor implicated in mitogen-activated signaling. J. Biol. Chem. 272: 5833-5837, 1997. 2. Hirayama, T., Shinozaki, K. A cdc5+ homolog of a higher plant, Arabidopsis thaliana. Proc. Nat. Acad. Sci. 93: 13371-13376, 1996. 3. St-Pierre, J., Douziech, M., Bazile, F., Pascariu, M., Bonneil, E., Sauve, V., Ratsima, H., D'Amours, D. Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity. Molec. Cell 34: 416-426, 2009. 4. Yoshida, S., Kono, K., Lowery, D. M., Bartolini, S., Yaffe, M. B., Ohya, Y., Pellman, D.Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 313: 108-111, 2006.
-
Gene Name
CDC5L
-
Protein Name
Cell division cycle 5-like protein
-
Gene Full Name
cell division cycle 5-like
-
Synonyms
CDC5 antibody|CDC5 cell division cycle 5-like(S. pombe) antibody|Cdc5 related protein antibody|CDC5-LIKE antibody|CDC5-like protein antibody|CEF1 antibody|Cell division cycle 5 S. pombe homolog of antibody|Cell division cycle 5-like protein antibody|dJ319D22.1 antibody|KIAA0432 antibody|PCDC5RP antibody|Pombe Cdc5 related protein antibody
-
Uniprot ID
Q99459
-
Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
