ca2 Antibody

• Catalog number
  PB9989
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  ca2
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  mouse
• Analyses
  WB,IHC-P
• Immunogen
  E.coli-derived human CA2 recombinant protein (Position: S2-K260). Human CA2 shares 81.1% and 80.7% amino acid (aa) sequence identity with mouse and rat CA2, respectively.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the ca2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The ca2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  CA2 is a cytosolic enzyme with the highest activity among all known CAs. The carbonic anhydrases (ACs) form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs relatively slowly in the absence of a catalyst. Mutations in the CA2 gene result in the CA II deficiency syndrome, an autosomal recessive disorder that produces osteopetrosis, renal tubular acidosis and cerebral calcification. This gene is mapped to 8q22.
• Related articles
  1. Aramaki, S., Yoshida, I., Yoshino, M., Kondo, M., Sato, Y., Noda, K., Jo, R., Okue, A., Sai, N., Yamashita, F. Carbonic anhydrase II deficiency in three unrelated Japanese patients. J. Inherit. Metab. Dis. 16: 982-990, 1993. 2. Laitala, T., Vaananen, H. K. Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase. J. Clin. Invest. 93: 2311-2318, 1994. 3. Venta, P. J., Welty, R. J., Johnson, T. M., Sly, W. S., Tashian, R. E. Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107his-to-tyr): complete structure of the normal human CA II gene. Am. J. Hum. Genet. 49: 1082-1090, 1991.
• Gene Name
  CA2
• Protein Name
  Carbonic anhydrase 2
• Gene Full Name
  carbonic anhydrase II
• Synonyms
  4.2.1.1 | CA2 | CAC | CAH2 | CAII | CA-II | Carbonate dehydratase II | Carbonic anhydrase 2 | Carbonic anhydrase B | Carbonic anhydrase C | Carbonic Anhydrase II | Carbonic dehydratase | P00918
• Uniprot ID
  P00918
• Entrez GeneID
  760
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ca2  
• Gene symbol
  CRACR2B, CRACR2A, CA2
• Short name
  ca2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  ca2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:28703
• Gene
  CRACR2B
• Long gene name
  calcium release activated channel regulator 2B
• Synonyms gene
  • EFCAB4A
• Synonyms gene name
  • EF-hand calcium binding domain 4A
• Synonyms
  • MGC45840
• Synonyms name
  • Ca2+ release-activated Ca2+ (CRAC) channel regulator 2B
  • CRAC regulator 2B
• GenBank acession
  • BC073821
• Locus
  11p15.5
• Discovery year
  2006-03-21
• Entrez gene record
  283229
• Pubmed identfication
  • 20418871
• RefSeq identity
  • NM_173584
• Classification
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000165267

Gene info

• Identity
  HGNC:28657
• Gene
  CRACR2A
• Long gene name
  calcium release activated channel regulator 2A
• Synonyms gene
  • EFCAB4B
• Synonyms gene name
  • EF-hand calcium binding domain 4B
• Synonyms
  • MGC4266
  • RAB46
• Synonyms name
  • Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A
  • CRAC regulator 2A
• GenBank acession
  • BC004524
• Locus
  12p13.32
• Discovery year
  2006-03-21
• Entrez gene record
  84766
• Pubmed identfication
  • 20418871
  • 31092558
• RefSeq identity
  • NM_032680
• Classification
  • EF-hand domain containing

Gene info

• Identity
  HGNC:1373
• Gene
  CA2
• Long gene name
  carbonic anhydrase 2
• Synonyms gene name
  • carbonic anhydrase II
• Synonyms
  • Car2
  • CA-II
  • CAII
• GenBank acession
  • J03037
• Locus
  8q21.2
• Discovery year
  2001-06-22
• Entrez gene record
  760
• Pubmed identfication
  • 3107918
• RefSeq identity
  • NM_000067
• Classification
  • Carbonic anhydrases
• VEGA ID
  OTTHUMG00000164944

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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