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Target antigen
APPBP1
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
E.coli-derived human APPBP1 recombinant protein (Position: E181-L534). Human APPBP1 shares 98% amino acid (aa) sequence identity with mouse APPBP1.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the APPBP1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The APPBP1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
NAE1 is also known as APPBP1. The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
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Related articles
1. Hong BH, et al. Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. Neuroreport, 2012 Jan 25. 2. Joo Y, et al. Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells. PLoS One, 2010 Dec 2. 3. Zhong HJ, et al. A metal-based inhibitor of NEDD8-activating enzyme. PLoS One, 2012.
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Gene Name
NAE1
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Protein Name
NEDD8-activating enzyme E1 regulatory subunit
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Gene Full Name
NEDD8 activating enzyme E1 subunit 1
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Synonyms
59 kDa antibody|A 116A10.1 antibody|Amyloid beta precursor protein binding protein 1 59kD antibody|Amyloid beta precursor protein binding protein 1 59kDa antibody|Amyloid beta precursor protein binding protein 1 antibody|Amyloid beta precursor protein-binding protein 1 antibody|Amyloid protein binding protein 1 antibody|Amyloid protein-binding protein 1 antibody|APP BP1 antibody|APP-BP1 antibody|APPBP 1 antibody|HPP 1 antibody|HPP1 antibody|NAE 1 antibody|NAE1 antibody|NEDD8 activating enzyme E1 regulatory subunit antibody|NEDD8 activating enzyme E1 subunit 1 antibody|NEDD8 activating enzyme E1 subunit antibody|NEDD8-activating enzyme E1 regulatory subunit antibody|Proto oncogene protein 1 antibody|Proto-oncogene protein 1 antibody|Protooncogene protein 1 antibody|ula 1 antibody|ULA1_HUMAN antibody
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Uniprot ID
Q13564
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Entrez GeneID
8883
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
