Alpha A Crystallin Antibody

• Catalog number
  PB9940
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Alpha A Crystallin
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB,IHC-P
• Immunogen
  E. coli-derived human Alpha A Crystallin recombinant protein (Position: M1-S173). Human Alpha A Crystallin shares 94.8% amino acid (aa) sequence identity with both mouse and rat Alpha A Crystallin.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Alpha A Crystallin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Alpha A Crystallin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).
• Related articles
  1. "Entrez Gene: CRYAA crystallin, alpha A". 2. Derham BK, Harding JJ (1999). "Alpha-crystallin as a molecular chaperone.". Progress in retinal and eye research 18 (4): 463–509. 3. Jaworski CJ, Piatigorsky J (1989). "A pseudo-exon in the functional human alpha A-crystallin gene.". Nature337 (6209): 752–4.
• Gene Name
  CRYAA
• Protein Name
  Alpha-crystallin A chain
• Gene Full Name
  crystallin alpha A
• Synonyms
  Acry 1 | CRYA 1 | CRYA1 | CRYAA | Crystallin alpha 1 | Crystallin alpha A | HSPB 4 | HspB4 | P02489
• Uniprot ID
  P02489
• Entrez GeneID
  1409
• Description
  The Alpha A Crystallin Antibody is a α- or alpha protein sometimes glycoprotein present in blood.
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Alpha   Crystallin  
• Gene symbol
  CRYAA
• Short name
  Alpha A Crystallin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  a A Crystallin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2388
• Gene
  CRYAA
• Long gene name
  crystallin alpha A
• Synonyms gene
  • CRYA1
• Synonyms gene name
  • crystallin, alpha A
• Synonyms
  • HSPB4
• Locus
  21q22.3
• Discovery year
  1986-01-01
• Entrez gene record
  1409
• Classification
  • Small heat shock proteins
• VEGA ID
  OTTHUMG00000086842
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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