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Target antigen
5HT3A receptor
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
mouse
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human 5HT3A receptor(140-154aa RHQGEVQNYKPLQVV).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the 5HT3A receptor Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The 5HT3A receptor Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene. The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Related articles
1. "Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A". 2. Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (Jul 2003). "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature. 424 (6946): 321–4. 3. Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (Feb 1996). "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics. 29 (1): 304–5.
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Gene Name
HTR3A
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Protein Name
5-hydroxytryptamine receptor 3A(5-HT3-A/5-HT3A)
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Gene Full Name
5-hydroxytryptamine(serotonin) receptor 3A, ionotropic
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Synonyms
5 HT 3 antibody|5 HT3 receptor antibody|5 HT3A antibody|5 HT3A receptor antibody|5 HT3R antibody|5 HT3RA antibody|5 hydroxytryptamine(serotonin) receptor 3A antibody|5-HT-3 antibody|5-HT3-A antibody|5-HT3A antibody|5-HT3R antibody|5-hydroxytryptamine receptor 3 antibody|5-hydroxytryptamine receptor 3A antibody|5HT 3 antibody|5HT 3A antibody|5HT receptor antibody|5HT3 serotonin receptor antibody|5HT3A_HUMAN antibody|5HT3R antibody|HTR3 antibody|Htr3a antibody|Serotonin gated ion channel receptor antibody|Serotonin receptor 3A antibody|Serotonin-gated ion channel receptor 3a antibody|Serotonin-gated ion channel receptor antibody
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Uniprot ID
P46098
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translation
anticorps
