Recombinant Human Cell Death 1 Ligand 1/PD-L1/B7-H1/CD274 (C-His, variant)

• Catalog number
  CU88
• Price
  Please ask
• Size
  1mg

• Alternative names
  Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; CD274
• Description
  Recombinant Human Programmed Cell Death 1 Ligand 1 is produced by our Mammalian expression system and the target gene encoding Phe19-Thr239 is expressed with a 6His tag at the C-terminus.
• Expression
  Human Cells
• Tag
  C-His
• Endotoxin
  Less than 0.1 ng/ug (1 EU/ug)
• Accession
  Q9NZQ7
• TargetSequence
  Phe19-Thr239
• Shipping
  Ambient
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4
• Note
  For research use only.
• Additional description
  For cells, cell lines and tissues in culture till half confluency. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Death   Ligand   1/PD-L1/B7-H1/CD274   C-His   variant  
• Gene symbol
  CD274, PDCD1LG2, VSIR, H1-9P, HHLA2, RLN1, H1-8, RNY4P2, LRRC23, ENPP2
• Short name
  Recombinant Death 1 Ligand 1/PD-L1/B7-H1/CD274 (C-His, variant)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Bon Opus advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens cellular Death 1 Ligand 1/PD-L1/B7-H1/CD274 molecule (C-histidine, variant)
• Alternative technique
  rec
• Alternative to gene target
  CD274 molecule, CD274 and IDBG-47487 and ENSG00000120217 and 29126, protein binding, Cell surfaces, Cd274 and IDBG-157249 and ENSMUSG00000016496 and 60533, PD-L1 and IDBG-631351 and ENSBTAG00000000095 and 533834
• Tissue
  cell

Gene info

• Identity
  HGNC:17635
• Gene
  CD274
• Long gene name
  CD274 molecule
• Synonyms gene
  • PDCD1LG1
• Synonyms gene name
  • programmed cell death 1 ligand 1
  • CD274 antigen
• Synonyms
  • B7-H
  • B7H1
  • PD-L1
  • PDL1
  • B7-H1
• Synonyms name
  • B7 homolog 1
• GenBank acession
  • AF177937
• Locus
  9p24.1
• Discovery year
  2003-11-13
• Entrez gene record
  29126
• Pubmed identfication
  • 11015443
  • 10581077
• RefSeq identity
  • NM_014143
• Classification
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000019503

Gene info

• Identity
  HGNC:18731
• Gene
  PDCD1LG2
• Long gene name
  programmed cell death 1 ligand 2
• Synonyms
  • PD-L2
  • Btdc
  • PDL2
  • bA574F11.2
  • CD273
  • B7-DC
• Synonyms name
  • B7 dendritic cell molecule
• GenBank acession
  • AF344424
• Locus
  9p24.1
• Discovery year
  2003-11-14
• Entrez gene record
  80380
• Pubmed identfication
  • 11224527
• RefSeq identity
  • NM_025239
• Classification
  • B7 family
  • CD molecules
  • Immunoglobulin like domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000019504

Gene info

• Identity
  HGNC:30085
• Gene
  VSIR
• Long gene name
  V-set immunoregulatory receptor
• Synonyms gene
  • C10orf54
• Synonyms gene name
  • chromosome 10 open reading frame 54
• Synonyms
  • SISP1
  • GI24
  • B7-H5
  • B7H5
  • VISTA
  • PD-1H
  • Dies1
• Synonyms name
  • stress induced secreted protein 1
  • V-domain Ig suppressor of T cell activation
  • PDCD1 homolog
• GenBank acession
  • AF193048
• Locus
  10q22.1
• Discovery year
  2005-10-06
• Entrez gene record
  64115
• Pubmed identfication
  • 12975309
  • 24691993
  • 25279955
• RefSeq identity
  • NM_022153
• Classification
  • B7 family
  • V-set domain containing
• VEGA ID
  OTTHUMG00000018426

Gene info

• Identity
  HGNC:30616
• Gene
  H1-9P
• Long gene name
  H1.9 linker histone, pseudogene
• Synonyms gene
  • HILS1
  • H1-9
• Synonyms gene name
  • histone linker H1 domain, spermatid-specific 1
  • histone linker H1 domain, spermatid-specific 1 (pseudogene)
  • H1.9 linker histone (pseudogene)
• Synonyms
  • H1.9
• GenBank acession
  • AY286318
• Locus
  17q21.33
• Discovery year
  2005-12-16
• Entrez gene record
  373861
• Pubmed identfication
  • 12920187
  • 30068355
• RefSeq identity
  • NR_024193
• Classification
  • H1 histones
• VEGA ID
  OTTHUMG00000162025

Gene info

• Identity
  HGNC:4905
• Gene
  HHLA2
• Long gene name
  HERV-H LTR-associating 2
• Synonyms
  • B7H7
  • B7-H5
  • B7y
  • B7-H7
• GenBank acession
  • AF126162
• Locus
  3q13.13
• Discovery year
  1999-09-07
• Entrez gene record
  11148
• Pubmed identfication
  • 10444326
  • 23784006
  • 22488247
• RefSeq identity
  • NM_007072
• Classification
  • C1-set domain containing
  • V-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000159224

Gene info

• Identity
  HGNC:10026
• Gene
  RLN1
• Long gene name
  relaxin 1
• Synonyms gene name
  • relaxin 1 (H1)
• Synonyms
  • H1
• Synonyms name
  • prorelaxin H1
• Locus
  9p24.1
• Discovery year
  2001-06-22
• Entrez gene record
  6013
• Classification
  • Neuropeptides
• VEGA ID
  OTTHUMG00000019495

Gene info

• Identity
  HGNC:18463
• Gene
  H1-8
• Long gene name
  H1.8 linker histone
• Synonyms gene
  • H1FOO
• Synonyms gene name
  • H1 histone family, member O, oocyte-specific
  • H1 histone family member O oocyte specific
• GenBank acession
  • AY158091
• Locus
  3q22.1
• Discovery year
  2003-05-23
• Entrez gene record
  132243
• Pubmed identfication
  • 12408966
• RefSeq identity
  • NM_153833
• Classification
  • H1 histones
• VEGA ID
  OTTHUMG00000159541

Gene info

• Identity
  HGNC:10246
• Gene
  RNY4P2
• Long gene name
  RNY4 pseudogene 2
• Synonyms gene name
  • RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
  • RNA, Ro-associated Y4 pseudogene 2
• Synonyms
  • hY4.B7
• GenBank acession
  • M77130
• Locus
  17q21.31
• Discovery year
  1993-08-25
• Entrez gene record
  6088
• RefSeq identity
  • NG_005037

Gene info

• Identity
  HGNC:19138
• Gene
  LRRC23
• Long gene name
  leucine rich repeat containing 23
• Synonyms
  • B7
  • LRPB7
• GenBank acession
  • BC014450
• Locus
  12p13.31
• Discovery year
  2006-01-24
• Entrez gene record
  10233
• Pubmed identfication
  • 11830501
  • 11826754
• RefSeq identity
  • NM_006992
• VEGA ID
  OTTHUMG00000156668

Gene info

• Identity
  HGNC:3357
• Gene
  ENPP2
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 2
• Synonyms gene
  • PDNP2
• Synonyms
  • ATX
  • PD-IALPHA
• Synonyms name
  • autotaxin
• GenBank acession
  • D45421
• Locus
  8q24.12
• Discovery year
  1995-08-10
• Entrez gene record
  5168
• Pubmed identfication
  • 8586446
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000164995

MeSH Data

• Name
  Radioimmunosorbent Test
• Concept
  Scope note: Radioimmunoassay of proteins using antibody coupled to an immunosorbent.
• Tree numbers
  • E05.478.566.380.830
  • E05.478.566.639.830
  • E05.601.470.380.830
  • E05.601.470.639.830
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

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