Recombinant Human C-C Motif Chemokine 2/CCL2/MCP-1

Alternative names

C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCL2
Description

Recombinant Human C-C Motif Chemokine 2 is produced by our E.coli expression system and the target gene encoding Gln24-Thr99 is expressed.
Expression

E. coli
Tag

tag free
Endotoxin

Less than 0.1 ng/ug (1 EU/ug)
Accession

P13500
TargetSequence

Gln24-Thr99
Shipping

Ambient
Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Note

For research use only.
Additional description

Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by Bon Opus in 1.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Source

Recombinants or rec. proteins
Group

recombinants

Gene target

C-C Motif Chemokine 2/CCL2/MCP-1
Gene symbol

CCL2, SMC4, PFDN4, JUN, FOS, TAC4, PCK1, MYB, ROS1
Short name

Recombinant C-C Motif Chemokine 2/CCL2/MCP-1
Technique

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Bon Opus advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Species

Human, Humans
Alternative name

Rec. H. sapiens C-C Motif Chemokine 2/chemokine (C-C motif) ligand 2/MCP-1
Alternative technique

rec
Alternative to gene target

chemokine (C-C motif) ligand 2, GDCF-2 and HC11 and HSMCR30 and MCAF and MCP-1 and MCP1 and SCYA2 and SMC-CF, CCL2 and IDBG-40504 and ENSG00000108691 and 6347, CCR2 chemokine receptor binding, Extracellular, Ccl2 and IDBG-204473 and ENSMUSG00000035385 and 20296, CCL2 and IDBG-630954 and ENSBTAG00000037811 and 281043

Identity

HGNC:10618
Gene

CCL2
Long gene name

C-C motif chemokine ligand 2
Synonyms gene
- SCYA2
Synonyms gene name
- small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
- chemokine (C-C motif) ligand 2
Synonyms
- MCP1
- MCP-1
- MCAF
- SMC-CF
- GDCF-2
- HC11
- MGC9434
Synonyms name
GenBank acession
- BC009716
Locus

17q12
Discovery year

1990-07-05
Entrez gene record

6347
Pubmed identfication
- 2004761
RefSeq identity
- NM_002982
Classification
- Chemokine ligands
VEGA ID

OTTHUMG00000132887

Identity

HGNC:14013
Gene

SMC4
Long gene name

structural maintenance of chromosomes 4
Synonyms gene
- SMC4L1
Synonyms gene name
- SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
- SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
Synonyms
- hCAP-C
- CAP-C
GenBank acession
- AF092564
Locus

3q25.33
Discovery year

2001-02-22
Entrez gene record

10051
Pubmed identfication
- 9789013
- 10319587
Classification
- Structural maintenance of chromosomes proteins
- Condensin I subunits
- Condensin II subunits
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000159006

Identity

HGNC:6204
Gene

JUN
Long gene name

Jun proto-oncogene, AP-1 transcription factor subunit
Synonyms gene name
- v-jun avian sarcoma virus 17 oncogene homolog
- jun oncogene
Synonyms
- c-Jun
- AP-1
GenBank acession
- AY217548
Locus

1p32.1
Discovery year

1988-05-11
Entrez gene record

3725
Pubmed identfication
- 3194415
RefSeq identity
- NM_002228
Classification
- Basic leucine zipper proteins
- Jun transcription factor family
VEGA ID

OTTHUMG00000008376

Identity

HGNC:3796
Gene

FOS
Long gene name

Fos proto-oncogene, AP-1 transcription factor subunit
Synonyms gene name
- v-fos FBJ murine osteosarcoma viral oncogene homolog
- FBJ murine osteosarcoma viral oncogene homolog
Synonyms
- c-fos
- AP-1
GenBank acession
- K00650
Locus

14q24.3
Discovery year

2001-06-22
Entrez gene record

2353
Pubmed identfication
RefSeq identity
- NM_005252
Classification
- Fos transcription factor family
- Basic leucine zipper proteins
VEGA ID

OTTHUMG00000171774

Identity

HGNC:10261
Gene

ROS1
Long gene name

ROS proto-oncogene 1, receptor tyrosine kinase
Synonyms gene name
- v-ros avian UR2 sarcoma virus oncogene homolog 1
- v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
- c-ros oncogene 1 , receptor tyrosine kinase
Synonyms
- MCF3
- ROS
- c-ros-1
GenBank acession
- M13599
Locus

6q22.1
Discovery year

1986-01-01
Entrez gene record

6098
Pubmed identfication
- 1611909
Classification
- Receptor tyrosine kinases
- Fibronectin type III domain containing
VEGA ID

OTTHUMG00000016188
Locus Specific Databases
- LRG_997

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data