Recombinant Human 4-1BB Ligand/4-1BBL/TNFSF9/CD137L (N-Fc)

Alternative names

Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL; TNFSF9
Description

Recombinant Human 4-1BB Ligand is produced by our Mammalian expression system and the target gene encoding Arg71-Glu254 is expressed with a Fc tag at the N-terminus.
Expression

Human Cells
Tag

N-Fc
Endotoxin

Less than 0.1 ng/ug (1 EU/ug)
Accession

P41273
TargetSequence

Arg71-Glu254
Shipping

Ambient
Formulation

Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Note

For research use only.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional description

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Source

Recombinants or rec. proteins
Group

recombinants

Gene target

4-1BB Ligand/4-1BBL/TNFSF9/CD137L N-Fc
Gene symbol

TNFSF9, TNFRSF9, MIR1302-4, PIRC18, PIRC16, SNORD114-4, IGKV2OR2-4, MIR941-4
Short name

Recombinant 4-1BB Ligand/4-1BBL/TNFSF9/CD137L (N-Fc)
Technique

Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Bon Opus advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Species

Human, Humans
Alternative name

Rec. H. sapiens 4-1BB Ligand/4-1BBL/tumor necrosis factor (ligand) superfamily, member 9/CD137L (N-fragment c)
Alternative technique

rec
Alternative to gene target

tumor necrosis factor (ligand) superfamily, member 9, 4-1BB-L and CD137L, TNFSF9 and IDBG-21688 and ENSG00000125657 and 8744, tumor necrosis factor receptor superfamily binding, Extracellular, Tnfsf9 and IDBG-193693 and ENSMUSG00000035678 and 21950, TNFSF9 and IDBG-643947 and ENSBTAG00000046266 and 521748

Identity

HGNC:5809
Gene

IGKV2OR2-4
Long gene name

immunoglobulin kappa variable 2/OR2-4 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
Synonyms
- IGKV2/OR2-4
GenBank acession
- X51883
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28858
Pubmed identfication
- 2111145
Classification
- Immunoglobulin kappa (IGK) orphons

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data