ZSTK474

• Catalog number
  1597-100
• Price
  Please ask
• Size
  100 mg

• Alternative_name
  4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine
• Description
  ZSTK474 is a reversible, potent and specific inhibitor of phosphoinositide 3-kinase (PI3K) isoforms ((IC₅₀s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). More effective than LY 294,002 in vitro and as in vivo. Displays strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice.
• CAS Number
  475110-96-4
• Structure Available
  Yes
• Molecular Formula
  C₁₉H₂₁F₂N₇O₂S
• Molecular Weight
  417.41
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and specific phosphoinositide 3-kinase (PI3K) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  11647372
• PubChem CID Link
• SMILES
  C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5
• InChi
  InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
• InChi Key
  HGVNLRPZOWWDKD-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ZSTK474  
• Short name
  ZSTK474
• Alternative name
  ZSTK474

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