Z-VRPR-FMK

Alternative_name

Z-VRPR-FMK trifluoroacetate salt
Description

Z-VRPR-FMK is selective and irreversible MALT-1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor that inhibits NF- κB dependent gene expression affecting the growth, proliferation and survival of hyperactive B cell like in diffuse large B-cell lymphomas (ABC-DLBCL). It has also shown to inhibit autoprocessing activity of MCA2 in protozoan species
CAS Number

1381885-28-4 (free base)
Structure Available

Yes
Peptide sequence

Z-VRPR-FMK
Salt Form

Yes
Molecular Formula

C₃₁H₄₉FN₁₀O₆.CF₃CO₂H
Molecular Weight

790.81
Cell Permeable

Yes
Purity

≥90% by HPLC
Solubilities

H₂O (~ 1 mg/ml)
Handling

Protect from air and moisture
Tag Line

A selective and irreversible MALT-1 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

121513848
PubChem CID Link
SMILES

CC(C)C(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)CF)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O
InChi

InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34;3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38);(H,6,7)/t21?,22-,23-,25-;/m0./s1
InChi Key

WIPHXOQUHDJLCU-WTJMUODPSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:9544
Gene

PSMB7
Long gene name

proteasome 20S subunit beta 7
Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
Synonyms
- Z
Synonyms name
- proteasome subunit β2
GenBank acession
- AJ420455
Locus

9q33.3
Discovery year

1995-11-22
Entrez gene record

5695
Pubmed identfication
- 8811196
RefSeq identity
- NM_002799
Classification
- Proteasome
VEGA ID

OTTHUMG00000021042