XMU-MP-1

Alternative_name

XMU-MP1; XMUMP 1; 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamid
Description

XMU-MP-1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC₅₀ values are 38.1 and 71.1 nM for MST2 and MST1, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. Enhances activity of downstream YAP in vitro.
CAS Number

2061980-01-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₇H₁₆N₆O₃₃S₂
Molecular Weight

416.47
Cell Permeable

True
Purity

≥98%
Solubilities

>30 mg/ml in DMSO
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A potent and selective MST1/2 inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

121499143
PubChem CID Link
SMILES

CN1C2=C(C(=O)N(C3=CN=C(N=C31)NC4=CC=C(C=C4)S(=O)(=O)N)C)SC=C2
InChi

InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21)
InChi Key

YRDHKIFCGOZTGD-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

True

Gene target

XMU-MP-1
Gene symbol

PPP1CB, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1
Short name

XMU-MP-1
Alternative name

XMU-MP-1

Identity

HGNC:9282
Gene

PPP1CB
Long gene name

protein phosphatase 1 catalytic subunit beta
Synonyms gene name
- protein phosphatase 1, catalytic subunit, beta isoform
- protein phosphatase 1, catalytic subunit, beta isozyme
Synonyms
- PP1B
- PP-1B
- PP1beta
- PP1c
- MP
- PPP1beta
Synonyms name
- myosin phosphatase
Locus

2p23.2
Discovery year

1993-01-22
Entrez gene record

5500
Pubmed identfication
- 8312365
Classification
- Protein phosphatase catalytic subunits
VEGA ID

OTTHUMG00000152011

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081